PARN

PARN
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2A1R, 2A1S, 3CTR
Dynodwyr
Cyfenwau	PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease
Dynodwyr allanol	OMIM: 604212 HomoloGene: 31098 GeneCards: PARN
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • mRNA 3'-UTR binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • nuclease activity; • exonuclease activity; • hydrolase activity; • protein kinase binding; • cation binding; • RNA binding; • poly(A)-specific ribonuclease activity; • telomerase RNA binding; • 3'-5'-exoribonuclease activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nucleolus; • cnewyllyn cell;
Prosesau biolegol	• mRNA catabolic process; • female gamete generation; • regulation of mRNA stability; • GO:0016547 RNA modification; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • nuclear-transcribed mRNA poly(A) tail shortening; • RNA phosphodiester bond hydrolysis, exonucleolytic; • telomerase RNA stabilization; • positive regulation of telomere maintenance via telomerase; • positive regulation of telomerase activity; • regulation of telomerase RNA localization to Cajal body; • ncRNA deadenylation; • box H/ACA RNA 3'-end processing; • miRNA catabolic process; • polyadenylation-dependent snoRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologau
	5073
	n/a
	ENSG00000140694; ENSG00000274829
	n/a
	O95453
	n/a
	NM_001134477; NM_001242992; NM_002582
	n/a
	NP_001127949; NP_001229921; NP_002573
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARN yw PARN a elwir hefyd yn Poly(A)-specific ribonuclease (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARN.

DAN
DKCB6
PFBMFT4

Llyfryddiaeth

"PARN Modulates Y RNA Stability and Its 3'-End Formation. ". Mol Cell Biol. 2017. PMID 28760775.
"Rare Genetic Variants in PARN Are Associated with Pulmonary Fibrosis in Families. ". Am J Respir Crit Care Med. 2017. PMID 28414520.
"Poly(A)-specific ribonuclease is a nuclear ribosome biogenesis factor involved in human 18S rRNA maturation. ". Nucleic Acids Res. 2017. PMID 28402503.
"Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells. ". Nucleic Acids Res. 2017. PMID 27899605.
"Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.". J Clin Invest. 2015. PMID 25893599.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PARN - Cronfa NCBI

[1]

[2]