PARP3

PARP3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Dynodwyr
Cyfenwau	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
Dynodwyr allanol	OMIM: 607726 HomoloGene: 4005 GeneCards: PARP3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • glycosyltransferase activity; • catalytic activity; • NAD+ ADP-ribosyltransferase activity; • DNA ligase (ATP) activity; • protein ADP-ribosylase activity; • GO:0001948, GO:0016582 protein binding; • NAD DNA ADP-ribosyltransferase activity;
Cydrannau o'r gell	• cytoplasm; • site of double-strand break; • centriole; • Cytosgerbwd; • cnewyllyn cell; • microtubule organizing center; • nucleolus; • Cromosom;
Prosesau biolegol	• protein localization to site of double-strand break; • DNA ligation involved in DNA repair; • lagging strand elongation; • regulation of mitotic spindle organization; • positive regulation of DNA ligation; • telomere maintenance; • double-strand break repair; • protein ADP-ribosylation; • GO:0100026 DNA repair; • negative regulation of telomerase RNA reverse transcriptase activity; • protein poly-ADP-ribosylation; • DNA ADP-ribosylation; • negative regulation of isotype switching; • protein auto-ADP-ribosylation; • protein mono-ADP-ribosylation; • positive regulation of double-strand break repair via nonhomologous end joining; • cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologau
	10039
	n/a
	ENSG00000041880
	n/a
	Q9Y6F1
	n/a
	NM_001003931; NM_001003935; NM_005485; NM_001370239; NM_001370240
	n/a
	NP_001003931; NP_005476; NP_001357168; NP_001357169
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARP3 yw PARP3 a elwir hefyd yn Poly(ADP-ribose) polymerase family member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARP3.

IRT1
ARTD3
ADPRT3
ADPRTL2
ADPRTL3
PADPRT-3

Llyfryddiaeth

"Nick Your DNA, Mark Your Chromatin. ". Mol Cell. 2016. PMID 27716488.
"PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance. ". Tumour Biol. 2015. PMID 26040766.
"Reversible mono-ADP-ribosylation of DNA breaks. ". FEBS J. 2017. PMID 29054115.
"PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. ". Nucleic Acids Res. 2014. PMID 24598253.
"PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.". J Cell Biochem. 2007. PMID 16924674.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PARP3 - Cronfa NCBI

[1]

[2]