PARVA

PARVA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2K2R, 2VZC, 2VZD, 2VZG, 2VZI, 3KMU, 3KMW, 3REP
Dynodwyr
Cyfenwau	PARVA, CH-ILKBP, MXRA2, parvin alpha
Dynodwyr allanol	OMIM: 608120 HomoloGene: 10077 GeneCards: PARVA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • actin binding; • cadherin binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • Cellbilen; • cell junction; • Z discdkac; • Cytosgerbwd; • focal adhesion; • actin cytoskeleton; • cnewyllyn cell; • lamellipodium;
Prosesau biolegol	• actin cytoskeleton reorganization; • cilium assembly; • smooth muscle cell chemotaxis; • heterotypic cell-cell adhesion; • sprouting angiogenesis; • outflow tract septum morphogenesis; • establishment or maintenance of cell polarity; • chemotaxis; • actin-mediated cell contraction; • cell adhesion; • cell projection organization; • angiogenesis; • regulation of cell shape; • substrate adhesion-dependent cell spreading; • cell projection assembly;
	Sources:Amigo / QuickGO
Orthologau
	55742
	n/a
	ENSG00000197702
	n/a
	Q9NVD7
	n/a
	NM_018222
	n/a
	NP_060692
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PARVA yw PARVA a elwir hefyd yn Alpha-parvin a Parvin alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PARVA.

MXRA2
CH-ILKBP

Llyfryddiaeth

"Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. ". J Biol Chem. 2012. PMID 22955285.
"Involvement of β1-integrin via PIP complex and FAK/paxillin in dexamethasone-induced human mesenchymal stem cells migration. ". J Cell Physiol. 2011. PMID 20717960.
"α-Parvin, a pseudopodial constituent, promotes cell motility and is associated with lymph node metastasis of lobular breast carcinoma. ". Breast Cancer Res Treat. 2014. PMID 24496929.
"Suppression of actopaxin impairs hepatocellular carcinoma metastasis through modulation of cell migration and invasion. ". Hepatology. 2013. PMID 23504997.
"Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation.". PLoS One. 2012. PMID 23056266.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PARVA - Cronfa NCBI

[1]

[2]