PBX3

PBX3
Dynodwyr
Cyfenwau	PBX3, PBX homeobox 3
Dynodwyr allanol	OMIM: 176312 HomoloGene: 21243 GeneCards: PBX3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cnewyllyn cell; • transcription regulator complex;
Prosesau biolegol	• regulation of respiratory gaseous exchange by nervous system process; • adult locomotory behavior; • anterior compartment pattern formation; • dorsal spinal cord development; • neuron development; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • posterior compartment specification; • respiratory gaseous exchange by respiratory system; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologau
	5090
	n/a
	ENSG00000167081
	n/a
	P40426; Q96AL5
	n/a
	NM_001134778; NM_006195; NM_001330782
	n/a
	NP_001128250; NP_001317711; NP_006186; NP_006186.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PBX3 yw PBX3 a elwir hefyd yn Pre-B-cell leukemia transcription factor 3 a PBX homeobox 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q33.3.^[2]

Llyfryddiaeth

"Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects. ". Eur J Med Genet. 2012. PMID 22426282.
"Regulation of PBX3 expression by androgen and Let-7d in prostate cancer. ". Mol Cancer. 2011. PMID 21548940.
"PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia. ". Int J Cancer. 2017. PMID 28411381.
"PBX3 is a putative biomarker of aggressive prostate cancer. ". Int J Cancer. 2016. PMID 27273830.
"PBX3 is overexpressed in gastric cancer and regulates cell proliferation.". Tumour Biol. 2014. PMID 24375258.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PBX3 - Cronfa NCBI

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[2]