PCBP1

PCBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WVN, 1ZTG, 3VKE
Dynodwyr
Cyfenwau	PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC) binding protein 1
Dynodwyr allanol	OMIM: 601209 HomoloGene: 68506 GeneCards: PCBP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:0001948, GO:0016582 protein binding; • mRNA binding; • RNA binding; • nucleic acid binding; • single-stranded DNA binding; • sequence-specific single stranded DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • cadherin binding;
Cydrannau o'r gell	• cytoplasm; • extracellular exosome; • bilen; • cnewyllyn cell; • nucleoplasm; • cytosol; • nuclear speck; • cytoplasmic ribonucleoprotein granule;
Prosesau biolegol	• mRNA splicing, via spliceosome; • viral RNA genome replication; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	5093
	n/a
	ENSG00000169564
	n/a
	Q15365
	n/a
	NM_006196
	n/a
	NP_006187
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCBP1 yw PCBP1 a elwir hefyd yn Poly(rC) binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCBP1.

HNRPX
HNRPE1
hnRNP-X
HEL-S-85
hnRNP-E1

Llyfryddiaeth

"Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value. ". Int J Clin Exp Pathol. 2015. PMID 26261610.
"The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma. ". Genes Chromosomes Cancer. 2015. PMID 26173642.
"Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells. ". J Nutr. 2017. PMID 28250194.
"Poly(C)-binding protein 1 mediates drug resistance in colorectal cancer. ". Oncotarget. 2017. PMID 28076324.
"Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia.". Diagn Pathol. 2015. PMID 26293996.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PCBP1 - Cronfa NCBI

[1]

[2]