PCBP2

PCBP2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2AXY, 2JZX, 2P2R, 2PQU, 2PY9
Dynodwyr
Cyfenwau	PCBP2, HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2
Dynodwyr allanol	OMIM: 601210 HomoloGene: 74536 GeneCards: PCBP2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • enzyme binding; • nucleic acid binding; • ubiquitin protein ligase binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • C-rich single-stranded DNA binding;
Cydrannau o'r gell	• extracellular exosome; • bilen; • focal adhesion; • nucleoplasm; • cytoplasm; • cnewyllyn cell; • cytosol; • GO:0097483, GO:0097481 postsynaptic density;
Prosesau biolegol	• mRNA splicing, via spliceosome; • negative regulation of defense response to virus; • proteasome-mediated ubiquitin-dependent protein catabolic process; • defense response to virus; • mRNA metabolic process; • negative regulation of type I interferon production; • immune system process; • innate immune response; • viral RNA genome replication; • IRES-dependent viral translational initiation; • RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	5094
	n/a
	ENSG00000197111
	n/a
	Q15366
	n/a
NM_031989; NM_001098620; NM_001128911; NM_001128912; NM_001128913;
	NM_001128914; NM_005016
	n/a
NP_001092090; NP_001122383; NP_001122384; NP_001122385; NP_001122386;
	NP_005007; NP_114366
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCBP2 yw PCBP2 a elwir hefyd yn Poly(rC)-binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCBP2.

HNRPE2
HNRNPE2
hnRNP-E2

Llyfryddiaeth

"Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. ". J Virol. 2014. PMID 24371074.
"Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. ". Cell Metab. 2012. PMID 22633452.
"Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. ". Acta Neuropathol Commun. 2017. PMID 28666471.
"Overexpression of PCBP2 contributes to poor prognosis and enhanced cell growth in human hepatocellular carcinoma. ". Oncol Rep. 2016. PMID 27748915.
"Poly (C)-binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis.". Pathol Res Pract. 2016. PMID 27461833.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PCBP2 - Cronfa NCBI

[1]

[2]