PCNA

PCNA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V
Dynodwyr
Cyfenwau	PCNA, ATLD2, proliferating cell nuclear antigen
Dynodwyr allanol	OMIM: 176740 HomoloGene: 1945 GeneCards: PCNA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• MutLalpha complex binding; • identical protein binding; • enzyme binding; • receptor tyrosine kinase binding; • DNA binding; • DNA polymerase binding; • damaged DNA binding; • dinucleotide insertion or deletion binding; • GO:0001948, GO:0016582 protein binding; • chromatin binding; • histone acetyltransferase binding; • estrogen receptor binding; • purine-specific mismatch base pair DNA N-glycosylase activity; • DNA polymerase processivity factor activity;
Cydrannau o'r gell	• cnewyllyn cell; • replisome; • nucleoplasm; • extracellular exosome; • DNA replication factor C complex; • centrosome; • PCNA complex; • nuclear replication fork; • PCNA-p21 complex; • replication fork; • nuclear body; • chromatin;
Prosesau biolegol	• replication fork processing; • translesion synthesis; • DNA replication; • nucleotide-excision repair, DNA gap filling; • protein sumoylation; • regulation of DNA replication; • transcription-coupled nucleotide-excision repair; • positive regulation of deoxyribonuclease activity; • nucleotide-excision repair, DNA incision; • error-free translesion synthesis; • GO:1900404 positive regulation of DNA repair; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • positive regulation of DNA replication; • response to lipid; • heart development; • DNA mismatch repair; • cellular response to DNA damage stimulus; • mitotic telomere maintenance via semi-conservative replication; • epithelial cell differentiation; • response to cadmium ion; • cell population proliferation; • telomere maintenance; • error-prone translesion synthesis; • cellular response to UV; • estrous cycle; • cellular response to hydrogen peroxide; • response to dexamethasone; • nucleotide-excision repair, DNA incision, 5'-to lesion; • liver regeneration; • response to estradiol; • GO:0001306 response to oxidative stress; • GO:0100026 DNA repair; • response to L-glutamate; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • DNA ligation; • leading strand elongation; • protein ubiquitination; • telomere maintenance via semi-conservative replication; • GO:0022415 viral process;
	Sources:Amigo / QuickGO
Orthologau
	5111
	n/a
	ENSG00000132646
	n/a
	P12004
	n/a
	NM_182649; NM_002592
	n/a
	NP_002583; NP_872590
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PCNA yw PCNA a elwir hefyd yn Proliferating cell nuclear antigen (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p12.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PCNA.

ATLD2

Llyfryddiaeth

"The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies. ". Medicine (Baltimore). 2017. PMID 29019895.
"The dark side of the ring: role of the DNA sliding surface of PCNA. ". Crit Rev Biochem Mol Biol. 2017. PMID 28814116.
"Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. ". Mol Cell. 2017. PMID 28157503.
"PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. ". DNA Repair (Amst). 2017. PMID 28073635.
"Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal.". DNA Repair (Amst). 2016. PMID 27793507.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PCNA - Cronfa NCBI

[1]

[2]