PDCD1

PDCD1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2M2D, 3RRQ, 4ZQK
Dynodwyr
Cyfenwau	PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
Dynodwyr allanol	OMIM: 600244 HomoloGene: 3681 GeneCards: PDCD1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • signal transducer activity;
Cydrannau o'r gell	• integral component of membrane; • Cellbilen; • bilen; • external side of plasma membrane;
Prosesau biolegol	• positive regulation of apoptotic process; • multicellular organism development; • T cell costimulation; • negative regulation of apoptotic process; • positive regulation of T cell apoptotic process; • humoral immune response; • negative regulation of tolerance induction; • immune system process; • GO:0097285 apoptotic process; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	5133
	n/a
	ENSG00000188389; ENSG00000276977
	n/a
	Q15116
	n/a
	NM_005018
	n/a
	NP_005009
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD1 yw PDCD1 a elwir hefyd yn Programmed cell death 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD1.

PD1
PD-1
CD279
SLEB2
hPD-1
hPD-l
hSLE1

Llyfryddiaeth

"Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes. ". PLoS One. 2017. PMID 28877189.
"Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese. ". Invest Ophthalmol Vis Sci. 2017. PMID 28846771.
"Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. ". J Immunol. 2017. PMID 28916523.
"PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. ". Cancer Res. 2017. PMID 28904066.
"Increased Expression of Programmed Cell Death-1 in Regulatory T Cells of Patients with Severe Sepsis and Septic Shock: An Observational Clinical Study.". Scand J Immunol. 2017. PMID 28888058.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PDCD1 - Cronfa NCBI

[1]

[2]