PDCD10

PDCD10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3AJM, 3L8I, 3L8J, 3RQE, 3RQF, 3RQG, 3W8H, 3W8I, 4GEH, 4TVQ
Dynodwyr
Cyfenwau	PDCD10, CCM3, TFAR15, programmed cell death 10
Dynodwyr allanol	OMIM: 609118 HomoloGene: 10505 GeneCards: PDCD10
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • protein N-terminus binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • Golgi apparatus; • bilen; • Golgi membrane; • Cellbilen; • extracellular exosome;
Prosesau biolegol	• intrinsic apoptotic signaling pathway in response to hydrogen peroxide; • positive regulation of MAP kinase activity; • positive regulation of cell migration; • protein stabilization; • negative regulation of apoptotic process; • negative regulation of gene expression; • establishment of Golgi localization; • stress fiber assembly; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of protein serine/threonine kinase activity; • Golgi reassembly; • negative regulation of cell migration involved in sprouting angiogenesis; • GO:1901313 positive regulation of gene expression; • angiogenesis; • positive regulation of cell population proliferation; • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • regulation of Rho protein signal transduction; • response to hydrogen peroxide; • wound healing, spreading of cells; • positive regulation of Notch signaling pathway; • positive regulation of stress-activated MAPK cascade; • GO:0097285 apoptotic process; • positive regulation of intracellular protein transport; • cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologau
	11235
	n/a
	ENSG00000114209
	n/a
	Q9BUL8
	n/a
	NM_007217; NM_145859; NM_145860
	n/a
	NP_009148; NP_665858; NP_665859
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD10 yw PDCD10 a elwir hefyd yn Programmed cell death 10, isoform CRA_b a Programmed cell death 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q26.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD10.

CCM3
TFAR15

Llyfryddiaeth

"Detection of Novel Mutation in Ccm3 Causes Familial Cerebral Cavernous Malformations. ". J Mol Neurosci. 2015. PMID 26115622.
"The cerebral cavernous malformation 3 gene is necessary for senescence induction. ". Aging Cell. 2015. PMID 25655101.
"Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma. ". BMC Cancer. 2015. PMID 26490252.
"Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth. ". Neuro Oncol. 2016. PMID 26254477.
"Cerebral cavernous malformations associated to meningioma: High penetrance in a novel family mutated in the PDCD10 gene.". Neuroradiol J. 2015. PMID 26246098.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PDCD10 - Cronfa NCBI

[1]

[2]