PDCD4

PDCD4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
Dynodwyr
Cyfenwau	PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
Dynodwyr allanol	OMIM: 608610 HomoloGene: 7879 GeneCards: PDCD4
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • RNA binding;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • cytosol; • nucleoplasm;
Prosesau biolegol	• regulation of protein metabolic process; • negative regulation of cell cycle; • negative regulation of apoptotic process; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of JUN kinase activity; • positive regulation of smooth muscle cell apoptotic process; • negative regulation of myofibroblast differentiation; • GO:0097285 apoptotic process; • positive regulation of endothelial cell apoptotic process; • BMP signaling pathway; • epithelial to mesenchymal transition involved in cardiac fibroblast development; • negative regulation of vascular associated smooth muscle cell differentiation; • positive regulation of inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of cytokine production involved in inflammatory response; • positive regulation of NIK/NF-kappaB signaling; • interleukin-12-mediated signaling pathway; • negative regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	27250
	n/a
	ENSG00000150593
	n/a
	Q53EL6
	n/a
	NM_145341; NM_001199492; NM_014456
	n/a
	NP_001186421; NP_055271; NP_663314
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDCD4 yw PDCD4 a elwir hefyd yn Programmed cell death protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDCD4.

H731

Llyfryddiaeth

"Reduced PDCD4 Expression Promotes Cell Growth Through PI3K/Akt Signaling in Non-Small Cell Lung Cancer. ". Oncol Res. 2016. PMID 26802652.
"Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. ". Breast Cancer Res Treat. 2015. PMID 26026468.
"The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis. ". Chin J Cancer. 2016. PMID 27852288.
"Hypermethylation and Expression Silencing of PDCD4 Gene in Hepatocellular Carcinoma: A Consort Study. ". Medicine (Baltimore). 2016. PMID 26871813.
"Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome.". Fertil Steril. 2016. PMID 26868993.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PDCD4 - Cronfa NCBI

[1]

[2]