PDE4B

PDE4B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F
Dynodwyr
Cyfenwau	PDE4B, DPDE4, PDEIVB, phosphodiesterase 4B
Dynodwyr allanol	OMIM: 600127 HomoloGene: 1953 GeneCards: PDE4B
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • 3',5'-cyclic-nucleotide phosphodiesterase activity; • hydrolase activity; • cAMP binding; • gamma-tubulin binding; • transmembrane transporter binding; • phosphoric diester hydrolase activity; • 3',5'-cyclic-AMP phosphodiesterase activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• voltage-gated calcium channel complex; • gamma-tubulin complex; • cyrion cell; • cytosol; • GO:0097483, GO:0097481 postsynaptic density; • dendritic spine; • bilen; • centrosome; • Z discdkac; • excitatory synapse; • synaptic vesicle;
Prosesau biolegol	• regulation of high voltage-gated calcium channel activity; • neutrophil homeostasis; • regulation of cardiac muscle cell contraction; • positive regulation of interferon-gamma production; • GO:0072468 signal transduction; • cellular response to lipopolysaccharide; • positive regulation of interleukin-2 production; • leukocyte migration; • negative regulation of relaxation of cardiac muscle; • cellular response to epinephrine stimulus; • T cell receptor signaling pathway; • neutrophil chemotaxis; • cAMP catabolic process; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	5142
	n/a
	ENSG00000184588
	n/a
	Q07343
	n/a
NM_001037339; NM_001037340; NM_001037341; NM_001297440; NM_001297441;
	NM_001297442; NM_002600
	n/a
NP_001032416; NP_001032417; NP_001032418; NP_001284369; NP_001284370;
	NP_001284371; NP_002591; NP_001032418.1; NP_002591.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE4B yw PDE4B a elwir hefyd yn cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p31.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE4B.

DPDE4
PDEIVB

Llyfryddiaeth

"Expression of Phosphodiesterase 4B cAMP-Specific Gene in Subjects With Cryptorchidism and Down's Syndrome. ". J Clin Lab Anal. 2016. PMID 25546171.
"Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer. ". Prostate. 2012. PMID 22529021.
"Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies. ". PLoS One. 2016. PMID 26756575.
"The role of phosphodiesterase 4B in IL-8/LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase 4B inhibitor. ". Acta Pharm. 2015. PMID 26011935.
"Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population.". Gen Physiol Biophys. 2015. PMID 25926551.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PDE4B - Cronfa NCBI

[1]

[2]