PDK4

PDK4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2E0A, 2ZDX, 2ZDY, 2ZKJ, 3D2R
Dynodwyr
Cyfenwau	PDK4, pyruvate dehydrogenase kinase 4
Dynodwyr allanol	OMIM: 602527 HomoloGene: 129720 GeneCards: PDK4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • ATP binding; • pyruvate dehydrogenase (acetyl-transferring) kinase activity;
Cydrannau o'r gell	• mitochondrial matrix; • mitocondria;
Prosesau biolegol	• GO:1901047 insulin receptor signaling pathway; • glucose homeostasis; • regulation of fatty acid oxidation; • phosphorylation; • cellular response to starvation; • regulation of acetyl-CoA biosynthetic process from pyruvate; • regulation of fatty acid biosynthetic process; • reactive oxygen species metabolic process; • regulation of cellular ketone metabolic process; • regulation of glucose metabolic process; • cellular response to fatty acid; • glucose metabolic process; • response to starvation; • regulation of bone resorption; • negative regulation of anoikis; • regulation of pH; • protein phosphorylation; • carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	5166
	n/a
	ENSG00000004799
	n/a
	Q16654
	n/a
	NM_002612
	n/a
	NP_002603
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDK4 yw PDK4 a elwir hefyd yn Pyruvate dehydrogenase kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.3.^[2]

Llyfryddiaeth

"Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals. ". Eur J Nutr. 2015. PMID 25311062.
"Association of pyruvate dehydrogenase kinase 4 gene polymorphisms with type 2 diabetes and metabolic syndrome. ". Diabetes Res Clin Pract. 2012. PMID 22019269.
"Oncogenic role of PDK4 in human colon cancer cells. ". Br J Cancer. 2017. PMID 28208156.
"Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. ". Am J Pathol. 2016. PMID 27456128.
"Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance.". Exp Mol Pathol. 2015. PMID 25794976.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PDK4 - Cronfa NCBI

[1]

[2]