PEBP1

PEBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BD9, 1BEH, 2L7W, 2QYQ
Dynodwyr
Cyfenwau	PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1
Dynodwyr allanol	OMIM: 604591 HomoloGene: 37637 GeneCards: PEBP1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • lipid binding; • nucleotide binding; • protein kinase binding; • phosphatidylethanolamine binding; • serine-type endopeptidase inhibitor activity; • ATP binding; • enzyme binding; • peptidase inhibitor activity; • RNA binding; • signaling receptor binding; • mitogen-activated protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cnewyllyn cell; • extracellular exosome; • extracellular space; • mitocondria; • mitochondrial outer membrane; • Golgi apparatus; • synaptic vesicle; • cell surface; • soma; • myelin sheath; • axon terminus; • apical part of cell;
Prosesau biolegol	• MAPK cascade; • negative regulation of peptidase activity; • negative regulation of endopeptidase activity; • regulation of neurotransmitter levels; • regulation of the force of heart contraction; • GO:0001306 response to oxidative stress; • GO:0010260 heneiddio; • response to heat; • response to wounding; • response to toxic substance; • response to organonitrogen compound; • response to activity; • hippocampus development; • negative regulation of MAPK cascade; • positive regulation of cAMP-mediated signaling; • response to ethanol; • positive regulation of mitotic nuclear division; • sperm capacitation; • response to corticosterone; • response to cAMP; • response to calcium ion; • positive regulation of acetylcholine metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	5037
	n/a
	ENSG00000089220
	n/a
	P30086
	n/a
	NM_002567
	n/a
	NP_002558
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PEBP1 yw PEBP1 a elwir hefyd yn Phosphatidylethanolamine binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PEBP1.

PBP
HCNP
PEBP
RKIP
HCNPpp
PEBP-1
HEL-210
HEL-S-34
HEL-S-96

Llyfryddiaeth

"PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. ". Cell. 2017. PMID 29053969.
"[Knockdown of Raf kinase inhibitor protein promotes the proliferation of LX-2 human hepatic stellate cells]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017. PMID 28031115.
"Prognostic value of phosphorylated Raf kinase inhibitory protein at serine 153 and its predictive effect on the clinical response to radiotherapy in nasopharyngeal carcinoma. ". Radiat Oncol. 2016. PMID 27647315.
"Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells. ". Fertil Steril. 2016. PMID 27565262.
"Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: an in vivo and in vitro study.". J Cancer Res Clin Oncol. 2016. PMID 27444299.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PEBP1 - Cronfa NCBI

[1]

[2]