PF4

PF4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Dynodwyr
Cyfenwau	PF4, CXCL4, PF-4, SCYB4, platelet factor 4
Dynodwyr allanol	OMIM: 173460 HomoloGene: 87791 GeneCards: PF4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• extracellular region; • platelet alpha granule lumen; • extracellular space; • cytoplasm; • collagen-containing extracellular matrix;
Prosesau biolegol	• cytokine-mediated signaling pathway; • chemokine-mediated signaling pathway; • positive regulation of macrophage differentiation; • platelet degranulation; • negative regulation of megakaryocyte differentiation; • positive regulation of cAMP-mediated signaling; • negative regulation of MHC class II biosynthetic process; • leukocyte chemotaxis; • chemotaxis; • response to lipopolysaccharide; • positive regulation of macrophage derived foam cell differentiation; • GO:1901313 positive regulation of gene expression; • regulation of cell population proliferation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of tumor necrosis factor production; • negative regulation of angiogenesis; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • inflammatory response; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of cytolysis; • platelet activation; • defense response; • positive regulation of neutrophil chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of megakaryocyte differentiation; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • neutrophil chemotaxis; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologau
	5196
	n/a
	ENSG00000163737
	n/a
	P02776
	n/a
	NM_002619; NM_001363352
	n/a
	NP_002610; NP_001350281
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PF4 yw PF4 a elwir hefyd yn Platelet factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PF4.

PF-4
CXCL4
SCYB4

Llyfryddiaeth

"CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells. ". J Immunol. 2017. PMID 28515281.
"Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair. ". J Clin Endocrinol Metab. 2017. PMID 28323919.
"Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation. ". J Biol Chem. 2017. PMID 28115521.
"Serum CXCL4 increase in primary Sjögren's syndrome characterizes patients with microvascular involvement and reduced salivary gland infiltration and lymph node involvement. ". Clin Rheumatol. 2016. PMID 27562035.
"CXC chemokine ligand 4 (CXCL4) is predictor of tumour angiogenic activity and prognostic biomarker in non-small cell lung cancer (NSCLC) patients undergoing surgical treatment.". Biomarkers. 2016. PMID 27098116.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PF4 - Cronfa NCBI

[1]

[2]