PHF6

PHF6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4NN2, 4R7A
Dynodwyr
Cyfenwau	PHF6, BFLS, BORJ, CENP-31, PHD finger protein 6
Dynodwyr allanol	OMIM: 300414 HomoloGene: 12375 GeneCards: PHF6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• tubulin binding; • enzyme binding; • scaffold protein binding; • DNA binding; • ribonucleoprotein complex binding; • GO:0031493 histone binding; • phosphoprotein binding; • histone deacetylase binding; • GO:0001948, GO:0016582 protein binding; • metal ion binding; • RNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • sequence-specific DNA binding;
Cydrannau o'r gell	• nucleolus; • chromosome, centromeric region; • cnewyllyn cell; • kinetochore; • nucleoplasm; • Cromosom;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologau
	84295
	n/a
	ENSG00000156531
	n/a
	Q8IWS0
	n/a
	NM_032458; NM_001015877; NM_032335
	n/a
	NP_001015877; NP_115711; NP_115834
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PHF6 yw PHF6 a elwir hefyd yn PHD finger protein 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq26.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PHF6.

BFLS
BORJ
CENP-31

Llyfryddiaeth

"Females with de novo aberrations in PHF6: clinical overlap of Borjeson-Forssman-Lehmann with Coffin-Siris syndrome. ". Am J Med Genet C Semin Med Genet. 2014. PMID 25099957.
"MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. ". Haematologica. 2014. PMID 24895337.
"The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events. ". Eur J Hum Genet. 2016. PMID 27165002.
"The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis. ". Tumour Biol. 2016. PMID 26561469.
"A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.". Genes Dev. 2015. PMID 25737277.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PHF6 - Cronfa NCBI

[1]

[2]