PIM2

PIM2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IWI, 4X7Q
Dynodwyr
Cyfenwau	PIM2, Pim-2 proto-oncogene, serine/threonine kinase
Dynodwyr allanol	OMIM: 300295 HomoloGene: 17098 GeneCards: PIM2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding Cydrannau o'r gell • cytoplasm Prosesau biolegol • phosphorylation • male meiotic nuclear division • response to virus • negative regulation of apoptotic process • protein phosphorylation • regulation of mitotic cell cycle • protein autophosphorylation • cell cycle • cell population proliferation • negative regulation of cell population proliferation • GO:0097285 apoptotic process • apoptotic mitochondrial changes • positive regulation of autophagy • positive regulation of macroautophagy • negative regulation of protein binding • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein stabilization • G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11040	n/a
Ensembl	ENSG00000102096	n/a
UniProt	Q9P1W9	n/a
RefSeq (mRNA)	NM_006875	n/a
RefSeq (protein)	NP_006866	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PIM2 yw PIM2 a elwir hefyd yn Pim-2 proto-oncogene, serine/threonine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp11.23.^[2]

Llyfryddiaeth

• "Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors. ". Int J Med Sci. 2015. PMID 26078709.
• "Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations. ". Biomed Res Int. 2015. PMID 26064888.
• "Pim2 is important for regulating DNA damage response in multiple myeloma cells. ". Blood Cancer J. 2016. PMID 27564460.
• "Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. ". Mol Cancer. 2015. PMID 26643319.
• "Control of Pim2 kinase stability and expression in transformed human haematopoietic cells.". Biosci Rep. 2015. PMID 26500282.

Cyfeiriadau

1. "Human PubMed Reference:".
2. PIM2 - Cronfa NCBI