PKM

PKM
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1T5A, 1ZJH, 3BJF, 3BJT, 3G2G, 3GQY, 3GR4, 3H6O, 3ME3, 3SRD, 3SRF, 3SRH, 3U2Z, 4B2D, 4FXF, 4FXJ, 4G1N, 4JPG, 4QG6, 4QG8, 4QG9, 4QGC, 4RPP, 4WJ8, 4YJ5
Dynodwyr
Cyfenwau	PKM, CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, pyruvate kinase, muscle, pyruvate kinase M1/2, p58
Dynodwyr allanol	OMIM: 179050 HomoloGene: 37650 GeneCards: PKM
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • potassium ion binding; • metal ion binding; • kinase activity; • catalytic activity; • GO:0001948, GO:0016582 protein binding; • MHC class II protein complex binding; • ATP binding; • magnesium ion binding; • pyruvate kinase activity; • RNA binding; • cadherin binding; • identical protein binding; • ADP binding; • thyroid hormone binding;
Cydrannau o'r gell	• cytoplasm; • extracellular vesicle; • fesigl; • GO:0005578 extracellular matrix; • myelin sheath; • cilium; • mitocondria; • extracellular exosome; • cnewyllyn cell; • extracellular region; • cytosol; • secretory granule lumen; • ficolin-1-rich granule lumen; • pyruvate kinase complex; • collagen-containing extracellular matrix;
Prosesau biolegol	• glycolytic process; • GO:0010703, GO:0010702 programmed cell death; • phosphorylation; • canonical glycolysis; • metabolaeth; • cellular response to insulin stimulus; • neutrophil degranulation; • response to hypoxia; • liver development; • glucose metabolic process; • ATP biosynthetic process; • response to nutrient; • response to gravity; • response to organic substance; • response to muscle inactivity; • animal organ regeneration; • response to insulin; • pyruvate biosynthetic process; • skeletal muscle tissue regeneration; • protein homotetramerization; • positive regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologau
	5315
	n/a
	ENSG00000067225
	n/a
	P14618
	n/a
NM_001206796; NM_001206797; NM_001206798; NM_001206799; NM_002654;
	NM_182470; NM_182471; NM_001316318
	n/a
NP_001193725; NP_001193726; NP_001193727; NP_001193728; NP_001303247;
	NP_002645; NP_872270; NP_872271
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKM yw PKM a elwir hefyd yn Pyruvate kinase PKM a Pyruvate kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKM.

PK3
TCB
OIP3
PKM2
CTHBP
THBP1
HEL-S-30

Llyfryddiaeth

"Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells. ". Cell Physiol Biochem. 2017. PMID 28746922.
"Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities. ". Cancer Res. 2017. PMID 28630053.
"Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer. ". Anticancer Res. 2018. PMID 29277786.
"LincRNA-p21 suppresses development of human prostate cancer through inhibition of PKM2. ". Cell Prolif. 2017. PMID 28994148.
"Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.". J Biol Chem. 2017. PMID 28778925.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PKM - Cronfa NCBI

[1]

[2]