PKN1

PKN1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CXZ, 1URF, 2RMK, 4NKG, 4OTD, 4OTG, 4OTH, 4OTI
Dynodwyr
Cyfenwau	PKN1, DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1, Protein kinase N1
Dynodwyr allanol	OMIM: 601032 HomoloGene: 48130 GeneCards: PKN1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • protein kinase C activity; • GO:0031493 histone binding; • histone deacetylase binding; • chromatin binding; • histone kinase activity (H3-T11 specific); • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • androgen receptor binding; • nuclear receptor coactivator activity; • ATP binding; • protein kinase C binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endosome; • bilen; • Cellbilen; • nucleoplasm; • midbody; • cleavage furrow; • cnewyllyn cell; • GO:0016023 cytoplasmic vesicle; • GO:0009327 protein-containing complex;
Prosesau biolegol	• regulation of germinal center formation; • GO:0033128 negative regulation of protein phosphorylation; • renal system process; • GO:0009373 regulation of transcription, DNA-templated; • B cell apoptotic process; • negative regulation of protein kinase activity; • phosphorylation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • B cell homeostasis; • spleen development; • hyperosmotic response; • transcription, DNA-templated; • regulation of cell motility; • protein phosphorylation; • GO:0035404 peptidyl-serine phosphorylation; • epithelial cell migration; • negative regulation of B cell proliferation; • regulation of immunoglobulin production; • GO:0072468 signal transduction; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • positive regulation of nucleic acid-templated transcription; • GO:0007243 intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	5585
	n/a
	ENSG00000123143
	n/a
	Q16512
	n/a
	NM_002741; NM_213560
	n/a
	NP_002732; NP_998725
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PKN1 yw PKN1 a elwir hefyd yn Serine/threonine-protein kinase N1 a Protein kinase N1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PKN1.

DBK
PKN
PAK1
PRK1
PAK-1
PRKCL1
PKN-ALPHA

Llyfryddiaeth

"PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. ". Hum Pathol. 2009. PMID 19427017.
"Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport. ". FEBS Lett. 2008. PMID 18519042.
"PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. ". Oncotarget. 2014. PMID 25504435.
"Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. ". Mol Cell Biol. 2014. PMID 24248594.
"Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.". J Biol Chem. 2013. PMID 24114839.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PKN1 - Cronfa NCBI

[1]

[2]