PLA2G1B

PLA2G1B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3ELO
Dynodwyr
Cyfenwau	PLA2G1B, PLA2, PLA2A, PPLA2, phospholipase A2 group IB
Dynodwyr allanol	OMIM: 172410 HomoloGene: 715 GeneCards: PLA2G1B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • calcium-dependent phospholipase A2 activity; • metal ion binding; • bile acid binding; • signaling receptor binding; • hydrolase activity; • phospholipase A2 activity; • phospholipid binding;
Cydrannau o'r gell	• secretory granule; • extracellular region; • cell surface; • extracellular space; • cytosol;
Prosesau biolegol	• phosphatidic acid biosynthetic process; • phosphatidylserine acyl-chain remodeling; • GO:0007243 intracellular signal transduction; • phosphatidylethanolamine acyl-chain remodeling; • positive regulation of calcium ion transport into cytosol; • lipid metabolism; • actin filament organization; • interleukin-8 production; • phosphatidylinositol acyl-chain remodeling; • GO:0043006 activation of phospholipase A2 activity; • neutrophil chemotaxis; • fatty acid biosynthetic process; • positive regulation of immune response; • innate immune response in mucosa; • positive regulation of NF-kappaB transcription factor activity; • phosphatidylglycerol acyl-chain remodeling; • positive regulation of protein secretion; • cellular response to insulin stimulus; • neutrophil mediated immunity; • leukotriene biosynthetic process; • phosphatidylcholine metabolic process; • phosphatidylcholine acyl-chain remodeling; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 signal transduction; • phospholipid metabolic process; • arachidonic acid secretion; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of glucose import; • positive regulation of cell population proliferation; • lipid catabolic process; • positive regulation of fibroblast proliferation; • antibacterial humoral response; • GO:0051637 defense response to Gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologau
	5319
	n/a
	ENSG00000170890
	n/a
	P04054
	n/a
	NM_000928
	n/a
	NP_000919
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLA2G1B yw PLA2G1B a elwir hefyd yn Phospholipase A2 group IB (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLA2G1B.

PLA2
PLA2A
PPLA2

Llyfryddiaeth[golygu | golygu cod]

"Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort. ". Eur J Hum Genet. 2006. PMID 16391564.
"Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns. ". Biochemistry. 2005. PMID 15736947.
"Structural insight into the activation mechanism of human pancreatic prophospholipase A2. ". J Biol Chem. 2009. PMID 19297324.
"Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases. ". Acta Ophthalmol Scand. 2007. PMID 17488462.
"Kinetics of group IB and IIA phospholipase A2 during low-volume continuous hemodiafiltration in severe acute pancreatitis.". Artif Organs. 2007. PMID 17470210.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] PLA2G1B - Cronfa NCBI

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[2]