PLCG1

PLCG1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1HSQ, 2HSP, 4EY0, 4FBN
Dynodwyr
Cyfenwau	PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, phospholipase C gamma 1
Dynodwyr allanol	OMIM: 172420 HomoloGene: 1997 GeneCards: PLCG1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • neurotrophin TRKA receptor binding; • receptor tyrosine kinase binding; • signal transducer activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • phosphoric diester hydrolase activity; • phospholipase C activity; • glutamate receptor binding; • hydrolase activity; • protein kinase binding; • phosphatidylinositol phospholipase C activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cell projection; • cell-cell junction; • ruffle; • Cellbilen; • COP9 signalosome; • lamellipodium; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • intracellular anatomical structure;
Prosesau biolegol	• GO:0007243 intracellular signal transduction; • Fc-gamma receptor signaling pathway involved in phagocytosis; • lipid metabolism; • positive regulation of epithelial cell migration; • positive regulation of release of sequestered calcium ion into cytosol; • in utero embryonic development; • inositol phosphate metabolic process; • positive regulation of angiogenesis; • cellular response to epidermal growth factor stimulus; • Fc-epsilon receptor signaling pathway; • lipid catabolic process; • positive regulation of blood vessel endothelial cell migration; • phospholipid catabolic process; • GO:0022415 viral process; • T cell receptor signaling pathway; • cell migration; • leukocyte migration; • calcium-mediated signaling; • epidermal growth factor receptor signaling pathway; • axon guidance; • positive regulation of vascular endothelial cell proliferation; • positive regulation of endothelial cell apoptotic process; • GO:0072468 signal transduction; • activation of phospholipase C activity; • positive regulation of phospholipase C activity; • modulation of chemical synaptic transmission; • calcium ion transport; • inositol trisphosphate biosynthetic process; • phosphatidylinositol-mediated signaling; • release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologau
	5335
	n/a
	ENSG00000124181
	n/a
	P19174
	n/a
	NM_002660; NM_182811
	n/a
	NP_002651; NP_877963
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLCG1 yw PLCG1 a elwir hefyd yn 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 a Phospholipase C gamma 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLCG1.

PLC1
NCKAP3
PLC-II
PLC148
PLCgamma1

Llyfryddiaeth

"Lentivirus-mediated PLCÎ³1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma. ". Oncotarget. 2016. PMID 26811493.
"PLCG1 Gene Mutations Are Uncommon in Cutaneous T-Cell Lymphomas. ". J Invest Dermatol. 2015. PMID 25910029.
"Phospholipase CÎ³ in Toll-like receptor-mediated inflammation and innate immunity. ". Adv Biol Regul. 2017. PMID 27707630.
"PLC-Î³1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. ". Virology. 2016. PMID 27310357.
"Immobilized epidermal growth factor stimulates persistent, directed keratinocyte migration via activation of PLCÎ³1.". FASEB J. 2016. PMID 27025961.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PLCG1 - Cronfa NCBI

[1]

[2]