PLXNB1

PLXNB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2JPH, 2OS6, 2R2O, 2REX, 3HM6, 3OL2, 3SU8, 3SUA
Dynodwyr
Cyfenwau	PLXNB1, PLEXIN-B1, PLXN5, SEP, plexin B1
Dynodwyr allanol	OMIM: 601053 HomoloGene: 130508 GeneCards: PLXNB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GTPase activating protein binding; • semaphorin receptor activity; • semaphorin receptor binding; • GO:0001948, GO:0016582 protein binding; • transmembrane signaling receptor activity; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • signaling receptor activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • semaphorin receptor complex; • integral component of plasma membrane; • extracellular region; • intracellular anatomical structure;
Prosesau biolegol	• ossification involved in bone maturation; • negative regulation of cell adhesion; • neuron projection morphogenesis; • GO:0007243 intracellular signal transduction; • positive regulation of axonogenesis; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • regulation of cell shape; • axon extension; • negative regulation of osteoblast proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • cell migration; • regulation of cytoskeleton organization; • semaphorin-plexin signaling pathway; • GO:0072468 signal transduction; • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • G protein-coupled receptor signaling pathway; • regulation of cell migration; • semaphorin-plexin signaling pathway involved in axon guidance; • inhibitory synapse assembly;
	Sources:Amigo / QuickGO
Orthologau
	5364
	n/a
	ENSG00000164050
	n/a
	O43157
	n/a
	NM_001130082; NM_002673
	n/a
	NP_001123554; NP_002664
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLXNB1 yw PLXNB1 a elwir hefyd yn Plexin B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLXNB1.

SEP
PLXN5
PLEXIN-B1

Llyfryddiaeth

"Function of mutant and wild-type plexinb1 in prostate cancer cells. ". Prostate. 2013. PMID 23775445.
"A dual binding mode for RhoGTPases in plexin signalling. ". PLoS Biol. 2011. PMID 21912513.
"Role of Plexin B1 in a Breast Cancer Cohort of Pakistani Patients and its Contribution Towards Cancer Metastasis as Indicated by an In VitroModel. ". Anticancer Res. 2017. PMID 28739743.
"Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1. ". Tumour Biol. 2016. PMID 26944058.
"Plexin-B1 signalling promotes androgen receptor translocation to the nucleus.". Oncogene. 2016. PMID 25982277.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PLXNB1 - Cronfa NCBI

[1]

[2]