POLA1

POLA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1K0P, 1K18, 1N5G, 4Q5V, 4QCL, 4Y97, 5EXR, 5IUD
Dynodwyr
Cyfenwau	POLA1, NSX, POLA, p180, Polymerase (DNA directed), alpha 1, polymerase (DNA) alpha 1, catalytic subunit, DNA polymerase alpha 1, catalytic subunit, VEODS
Dynodwyr allanol	OMIM: 312040 HomoloGene: 6802 GeneCards: POLA1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • 4 iron, 4 sulfur cluster binding; • nucleotidyltransferase activity; • nucleoside binding; • iron-sulfur cluster binding; • chromatin binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • protein kinase binding; • DNA-directed DNA polymerase activity; • nucleotide binding; • DNA binding; • DNA replication origin binding; • purine nucleotide binding; • protein heterodimerization activity; • single-stranded DNA binding; • pyrimidine nucleotide binding;
Cydrannau o'r gell	• nuclear envelope; • nuclear matrix; • nucleolus; • chromatin; • nucleoplasm; • cnewyllyn cell; • cytoplasm; • cytosol; • alpha DNA polymerase:primase complex;
Prosesau biolegol	• DNA synthesis involved in DNA repair; • lagging strand elongation; • regulation of transcription involved in G1/S transition of mitotic cell cycle; • DNA replication; • leading strand elongation; • cell population proliferation; • GO:0022415 viral process; • double-strand break repair via nonhomologous end joining; • DNA strand elongation involved in DNA replication; • DNA replication, synthesis of RNA primer; • telomere maintenance via semi-conservative replication; • G1/S transition of mitotic cell cycle; • DNA replication initiation; • GO:0100026 DNA repair; • nucleotide-excision repair; • DNA synthesis involved in UV-damage excision repair; • mitotic DNA replication initiation; • synthesis of RNA primer involved in mitotic DNA replication;
	Sources:Amigo / QuickGO
Orthologau
	5422
	n/a
	ENSG00000101868
	n/a
	P09884
	n/a
	NM_016937; NM_001330360; NM_001378303
	n/a
	NP_001317289; NP_058633; NP_001365232
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLA1 yw POLA1 a elwir hefyd yn DNA polymerase alpha 1, catalytic subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp22.11-p21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLA1.

NSX
POLA
p180

Llyfryddiaeth

"DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. ". Nat Immunol. 2016. PMID 27019227.
"Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit. ". J Biol Chem. 2015. PMID 25847248.
"Functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 due to X;6 translocation with an atypical X-inactivation pattern. ". Am J Med Genet A. 2017. PMID 28371302.
"Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction. ". DNA Repair (Amst). 2016. PMID 27235627.
"Human DNA polymerase α in binary complex with a DNA:DNA template-primer.". Sci Rep. 2016. PMID 27032819.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] POLA1 - Cronfa NCBI

[1]

[2]