POLD3

POLD3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1U76, 3E0J, 2N1G
Dynodwyr
Cyfenwau	POLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
Dynodwyr allanol	OMIM: 611415 HomoloGene: 38202 GeneCards: POLD3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • DNA-directed DNA polymerase activity;
Cydrannau o'r gell	• delta DNA polymerase complex; • cnewyllyn cell; • nucleoplasm; • cytoplasm;
Prosesau biolegol	• nucleotide-excision repair, DNA gap filling; • DNA synthesis involved in DNA repair; • DNA replication; • translesion synthesis; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair, DNA incision; • telomere maintenance; • DNA-dependent DNA replication; • nucleotide-excision repair, DNA incision, 5'-to lesion; • GO:0100026 DNA repair; • cellular response to DNA damage stimulus; • telomere maintenance via semi-conservative replication; • DNA mismatch repair; • DNA strand elongation involved in DNA replication; • DNA synthesis involved in UV-damage excision repair;
	Sources:Amigo / QuickGO
Orthologau
	10714
	n/a
	ENSG00000077514
	n/a
	Q15054
	n/a
	NM_006591; NM_001363597
	n/a
	NP_006582; NP_001350526
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POLD3 yw POLD3 a elwir hefyd yn DNA polymerase delta 3, accessory subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.4.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POLD3.

P66
P68
PPP1R128

Llyfryddiaeth

"Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage. ". Cell Cycle. 2012. PMID 22801543.
"Phosphorylation of the C subunit (p66) of human DNA polymerase delta. ". Biochem Biophys Res Commun. 2008. PMID 18157942.
"In vivo evidence for translesion synthesis by the replicative DNA polymerase Î´. ". Nucleic Acids Res. 2016. PMID 27185888.
"Multiple Forms of Human DNA Polymerase Delta Sub-Assembling in Cellular DNA Transactions. ". Curr Protein Pept Sci. 2016. PMID 26916162.
"Break-induced replication repair of damaged forks induces genomic duplications in human cells.". Science. 2014. PMID 24310611.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] POLD3 - Cronfa NCBI

[1]

[2]