PON1

PON1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1V04
Dynodwyr
Cyfenwau	PON1, ESA, MVCD5, PON, paraoxonase 1
Dynodwyr allanol	OMIM: 168820 HomoloGene: 68058 GeneCards: PON1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • protein homodimerization activity; • metal ion binding; • aryldialkylphosphatase activity; • arylesterase activity; • hydrolase activity; • phospholipid binding; • acyl-L-homoserine-lactone lactonohydrolase activity;
Cydrannau o'r gell	• blood microparticle; • intracellular membrane-bounded organelle; • spherical high-density lipoprotein particle; • high-density lipoprotein particle; • extracellular exosome; • extracellular region; • extracellular space;
Prosesau biolegol	• response to fatty acid; • positive regulation of transporter activity; • negative regulation of plasma lipoprotein oxidation; • lipid metabolism; • carboxylic acid catabolic process; • cholesterol metabolic process; • positive regulation of binding; • response to nutrient levels; • response to fluoride; • positive regulation of cholesterol efflux; • response to external stimulus; • organophosphate catabolic process; • aromatic compound catabolic process; • phosphatidylcholine metabolic process; • response to toxic substance; • GO:0098501, GO:0098502, GO:0006286 dephosphorylation; • lipoxygenase pathway;
	Sources:Amigo / QuickGO
Orthologau
	5444
	n/a
	ENSG00000005421
	n/a
	P27169
	n/a
	NM_000446
	n/a
	NP_000437
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PON1 yw PON1 a elwir hefyd yn Paraoxonase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PON1.

ESA
PON
MVCD5

Llyfryddiaeth

"The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study. ". Medicine (Baltimore). 2017. PMID 29049204.
"Correlation of PON1 polymorphisms with ankylosing spondylitis susceptibility: A case-control study in Chinese Han population. ". Medicine (Baltimore). 2017. PMID 29049176.
"The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. ". BMC Med Genet. 2017. PMID 29233102.
"[The role of lipoprotein-associated enzyme paraoxonase 1 and its polymorphisms in the pathogenesis of endothelial dysfunction and somatic complications in patients with alcoholism: Review ]. ". Patol Fiziol Eksp Ter. 2016. PMID 29215249.
"Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients.". PLoS One. 2017. PMID 29176871.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PON1 - Cronfa NCBI

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[2]