PPARA |
---|
|
Strwythurau |
---|
PDB | Human UniProt search: PDBe RCSB |
---|
Rhestr o ddynodwyr PDB |
---|
1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT |
|
|
Dynodwyr |
---|
Cyfenwau | PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha |
---|
Dynodwyr allanol | HomoloGene: 21047 GeneCards: PPARA |
---|
|
Ontoleg y genyn |
---|
Gweithrediad moleciwlaidd | • DNA binding • sequence-specific DNA binding • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948, GO:0016582 protein binding • ubiquitin conjugating enzyme binding • lipid binding • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • signaling receptor activity • GO:0032403 protein-containing complex binding • transcription coactivator binding • phosphatase binding • NFAT protein binding • MDM2/MDM4 family protein binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • fatty acid binding • nuclear receptor coactivator activity
|
---|
Cydrannau o'r gell | • cnewyllyn cell • nucleoplasm • RNA polymerase II transcription regulator complex
|
---|
Prosesau biolegol | • lipoprotein metabolic process • negative regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of fatty acid beta-oxidation • negative regulation of glycolytic process • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • negative regulation of blood pressure • lipid metabolism • proses rythmig • wound healing • negative regulation of leukocyte cell-cell adhesion • GO:1901227 negative regulation of transcription by RNA polymerase II • fatty acid transport • negative regulation of protein binding • negative regulation of appetite • circadian regulation of gene expression • transcription, DNA-templated • fatty acid metabolic process • behavioral response to nicotine • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of cholesterol storage • response to insulin • heart development • intracellular receptor signaling pathway • negative regulation of transcription regulatory region DNA binding • negative regulation of sequestering of triglyceride • regulation of circadian rhythm • regulation of fatty acid metabolic process • epidermis development • regulation of gene expression • enamel mineralization • positive regulation of gluconeogenesis • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • steroid hormone mediated signaling pathway • negative regulation of neuron death • positive regulation of fatty acid oxidation • regulation of lipid metabolic process • GO:0072468 signal transduction • multicellular organism development • hormone-mediated signaling pathway • cell differentiation • response to lipid • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of cell growth involved in cardiac muscle cell development
|
---|
Sources:Amigo / QuickGO |
|
Orthologau |
---|
Species | Bod dynol | Llygoden |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Lleoliad (UCSC) | n/a | n/a |
---|
PubMed search | [1] | n/a |
---|
Wicidata |
|
Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARA yw PPARA a elwir hefyd yn Peroxisome proliferator-activated receptor alpha a Peroxisome proliferator activated receptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.31.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPARA.
- PPAR
- NR1C1
- hPPAR
- PPARalpha
- "Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions. ". J Diabetes. 2017. PMID 27863018.
- "Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis. ". Tohoku J Exp Med. 2016. PMID 27644403.
- "Potential involvement of PPAR α activation in diminishing the hepatoprotective effect of fenofibrate in NAFLD: Accuracy of non- invasive panel in determining the stage of liver fibrosis in rats. ". Biomed Pharmacother. 2017. PMID 27930988.
- "Hepatitis B virus upregulates host expression of α-1,2-mannosidases viathe PPARα pathway. ". World J Gastroenterol. 2016. PMID 27920474.
- "PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques.". Laryngoscope. 2017. PMID 27896820.