PPARD

PPARD
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM
Dynodwyr
Cyfenwau	PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator activated receptor delta
Dynodwyr allanol	OMIM: 600409 HomoloGene: 4544 GeneCards: PPARD
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • GO:0001105 transcription coactivator activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • fatty acid binding; • GO:0001948, GO:0016582 protein binding; • linoleic acid binding; • protein heterodimerization activity; • lipid binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • transcription factor binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • NF-kappaB binding; • GO:0000975 transcription cis-regulatory region binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • nuclear receptor coactivator activity; • signaling receptor activity;
Cydrannau o'r gell	• nucleoplasm; • cnewyllyn cell; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• fatty acid catabolic process; • positive regulation of myoblast proliferation; • positive regulation of epidermis development; • cell differentiation; • negative regulation of smooth muscle cell proliferation; • negative regulation of myoblast differentiation; • GO:0009373 regulation of transcription, DNA-templated; • placenta development; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of smooth muscle cell migration; • wound healing; • mRNA transcription; • cholesterol metabolic process; • negative regulation of apoptotic process; • response to glucose; • response to activity; • response to organic substance; • generation of precursor metabolites and energy; • regulation of fat cell differentiation; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • response to vitamin A; • heart development; • cell-substrate adhesion; • keratinocyte proliferation; • GO:1901313 positive regulation of gene expression; • proteoglycan metabolic process; • regulation of cell population proliferation; • negative regulation of cell growth; • fatty acid oxidation; • positive regulation of cell population proliferation; • glucose metabolic process; • phospholipid biosynthetic process; • negative regulation of epithelial cell proliferation; • positive regulation of skeletal muscle tissue regeneration; • apoptotic signaling pathway; • vitamin A metabolic process; • positive regulation of phosphatidylinositol 3-kinase signaling; • keratinocyte migration; • adipose tissue development; • transcription initiation from RNA polymerase II promoter; • regulation of skeletal muscle satellite cell proliferation; • positive regulation of fat cell differentiation; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of inflammatory response; • cellular response to lipopolysaccharide; • cellular response to hypoxia; • negative regulation of collagen biosynthetic process; • positive regulation of insulin secretion; • steroid hormone mediated signaling pathway; • GO:0097285 apoptotic process; • cell population proliferation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • intracellular receptor signaling pathway; • axon ensheathment; • decidualization; • fatty acid transport; • embryo implantation; • negative regulation of pri-miRNA transcription by RNA polymerase II; • lipid metabolism; • fatty acid beta-oxidation; • glucose transmembrane transport; • fatty acid metabolic process; • multicellular organism development; • hormone-mediated signaling pathway; • negative regulation of cholesterol storage; • regulation of lipid metabolic process; • response to lipid; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	5467
	n/a
	ENSG00000112033
	n/a
	Q03181
	n/a
	NM_001171818; NM_001171819; NM_001171820; NM_006238; NM_177435
	n/a
	NP_001165289; NP_001165290; NP_001165291; NP_006229; NP_803184
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARD yw PPARD a elwir hefyd yn Peroxisome proliferator activated receptor delta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPARD.

FAAR
NUC1
NUCI
NR1C2
NUCII
PPARB

Llyfryddiaeth

"Circulating "LncPPARÎ´" From Monocytes as a Novel Biomarker for Coronary Artery Diseases. ". Medicine (Baltimore). 2016. PMID 26871769.
"Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. ". Eur J Pharmacol. 2016. PMID 26852954.
"Association of peroxisome proliferator-activated receptor delta and additional gene-smoking interaction on cardiovascular disease. ". Clin Exp Hypertens. 2017. PMID 28287878.
"PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions. ". Leukemia. 2017. PMID 28050012.
"PPARD rs2016520 polymorphism is associated with metabolic traits in a large population of Chinese adults.". Gene. 2016. PMID 26915488.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PPARD - Cronfa NCBI

[1]

[2]