PPBP

PPBP
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1TVX, 1F9P, 1NAP
Dynodwyr
Cyfenwau	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
Dynodwyr allanol	OMIM: 121010 HomoloGene: 136759 GeneCards: PPBP
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• growth factor activity; • cytokine activity; • glucose transmembrane transporter activity; • CXCR chemokine receptor binding; • chemokine activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• platelet alpha granule lumen; • extracellular region; • extracellular space; • tertiary granule lumen; • platelet alpha granule;
Prosesau biolegol	• response to lipopolysaccharide; • regulation of cell population proliferation; • chemotaxis; • positive regulation of cell division; • platelet degranulation; • defense response to bacterium; • inflammatory response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • chemokine-mediated signaling pathway; • defense response; • positive regulation of neutrophil chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • neutrophil degranulation; • cell chemotaxis; • G protein-coupled receptor signaling pathway; • glucose transmembrane transport; • neutrophil chemotaxis; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologau
	5473
	n/a
	ENSG00000163736
	n/a
	P02775
	n/a
	NM_002704
	n/a
	NP_002695
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPBP yw PPBP a elwir hefyd yn Pro-platelet basic protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPBP.

PBP
TC1
TC2
TGB
LDGF
MDGF
TGB1
B-TG1
CTAP3
CXCL7
NAP-2
SCYB7
THBGB
LA-PF4
THBGB1
Beta-TG
CTAPIII
CTAP-III

Llyfryddiaeth

"Expression level of CXCL7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma. ". Cancer Sci. 2017. PMID 28985012.
"Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions. ". Int J Mol Sci. 2017. PMID 28368308.
"CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells. ". Oncol Rep. 2017. PMID 27959418.
"Novel TIA biomarkers identified by mass spectrometry-based proteomics. ". Int J Stroke. 2015. PMID 26307429.
"Dynamics and thermodynamic properties of CXCL7 chemokine.". Proteins. 2015. PMID 26297927.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PPBP - Cronfa NCBI

[1]

[2]