PPP1CA

PPP1CA
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3E7A, 3E7B, 3EGG, 3EGH, 3HVQ, 3N5U, 3V4Y, 4G9J, 4MOV, 4MOY, 4MP0, 4XPN, 1FJM
Dynodwyr
Cyfenwau	PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A, protein phosphatase 1 catalytic subunit alpha
Dynodwyr allanol	OMIM: 176875 HomoloGene: 105262 GeneCards: PPP1CA
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phosphoprotein phosphatase activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • hydrolase activity; • cadherin binding involved in cell-cell adhesion; • protein serine/threonine phosphatase activity; • GO:0098519, GO:0098518 phosphatase activity; • protein phosphatase 1 binding; • ribonucleoprotein complex binding; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• cytoplasm; • Cellbilen; • nucleoplasm; • PTW/PP1 phosphatase complex; • nucleolus; • extracellular exosome; • cnewyllyn cell; • cytosol; • protein phosphatase type 1 complex; • glycogen granule; • neuron projection; • soma; • dendritic spine; • perikaryon; • presynapse; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• regulation of canonical Wnt signaling pathway; • negative regulation of protein binding; • Cellraniad; • glycogen metabolic process; • cell cycle; • regulation of translational initiation by eIF2 alpha dephosphorylation; • beta-catenin destruction complex disassembly; • GO:0098501, GO:0098502, GO:0006286 dephosphorylation; • cell-cell adhesion; • GO:0016576 protein dephosphorylation; • circadian regulation of gene expression; • regulation of circadian rhythm; • entrainment of circadian clock by photoperiod; • carbohydrate metabolic process; • regulation of glycogen biosynthetic process; • regulation of glycogen catabolic process; • response to lead ion; • lung development; • peptidyl-threonine dephosphorylation; • branching morphogenesis of an epithelial tube; • peptidyl-serine dephosphorylation; • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; • GO:0022415 viral process;
	Sources:Amigo / QuickGO
Orthologau
	5499
	n/a
	ENSG00000172531
	n/a
	P62136
	n/a
	NM_206873; NM_001008709; NM_002708
	n/a
	NP_001008709; NP_002699; NP_996756
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP1CA yw PPP1CA a elwir hefyd yn Serine/threonine-protein phosphatase PP1-alpha catalytic subunit a Protein phosphatase 1 catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP1CA.

PP1A
PP-1A
PPP1A
PP1alpha

Llyfryddiaeth

"The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. ". Exp Cell Res. 2015. PMID 25556058.
"Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. ". Cancer Res. 2010. PMID 20663907.
"Analysis of Autoantibodies Related to Tumor Progression in Sera from Patients with High-grade Non-muscle-invasive Bladder Cancer. ". Anticancer Res. 2017. PMID 29187447.
"Biogenesis and activity regulation of protein phosphatase 1. ". Biochem Soc Trans. 2017. PMID 28202662.
"Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells.". Apoptosis. 2015. PMID 26033480.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PPP1CA - Cronfa NCBI

[1]

[2]