PPP1R8

PPP1R8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3V4Y
Dynodwyr
Cyfenwau	PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8
Dynodwyr allanol	OMIM: 602636 HomoloGene: 8555 GeneCards: PPP1R8
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein serine/threonine phosphatase inhibitor activity; • DNA binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • protein phosphatase inhibitor activity; • nuclease activity; • endonuclease activity; • ribonuclease E activity; • hydrolase activity; • mRNA binding; • protein phosphatase regulator activity;
Cydrannau o'r gell	• cytoplasm; • nuclear speck; • nucleoplasm; • spliceosomal complex; • cnewyllyn cell;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • nucleic acid phosphodiester bond hydrolysis; • mRNA processing; • RNA catabolic process; • transcription, DNA-templated; • RNA splicing; • cell population proliferation; • RNA phosphodiester bond hydrolysis; • negative regulation of protein dephosphorylation; • negative regulation of phosphoprotein phosphatase activity; • regulation of phosphoprotein phosphatase activity; • production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologau
	5511
	n/a
	ENSG00000117751
	n/a
	Q12972
	n/a
	NM_138558; NM_002713; NM_014110
	n/a
	NP_002704; NP_054829; NP_612568
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP1R8 yw PPP1R8 a elwir hefyd yn Nuclear inhibitor of protein phosphatase 1 a Protein phosphatase 1 regulatory subunit 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p35.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP1R8.

ARD1
ARD-1
NIPP1
NIPP-1
PRO2047

Llyfryddiaeth

"Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. ". J Cell Sci. 2000. PMID 11034904.
"Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. ". Gene. 1999. PMID 10564811.
"Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells. ". FEBS Lett. 2015. PMID 25907536.
"The NMR structure of the NIPP1 FHA domain. ". J Biomol NMR. 2008. PMID 18253837.
"The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly.". J Biol Chem. 2002. PMID 11909864.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PPP1R8 - Cronfa NCBI

[1]

[2]