PPP3CA |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/06/Protein_PPP3CA_PDB_1aui.png/250px-Protein_PPP3CA_PDB_1aui.png) |
Strwythurau |
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PDB | Human UniProt search: PDBe RCSB |
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Rhestr o ddynodwyr PDB |
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1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V |
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Dynodwyr |
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Cyfenwau | PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91 |
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Dynodwyr allanol | OMIM: 114105 HomoloGene: 55497 GeneCards: PPP3CA |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn PPP3CA yw PPP3CA a elwir hefyd yn Protein phosphatase 3 catalytic subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q24.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPP3CA.
- CALN
- CCN1
- CNA1
- CALNA
- IECEE
- PPP2B
- CALNA1
- "Increased ratio of calcineurin immunoreactive neurons in the caudate nucleus of patients with schizophrenia. ". Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID 22285318.
- "The effect of down regulation of calcineurin Aα by lentiviral vector-mediated RNAi on the biological behavior of small-cell lung cancer and its bone metastasis. ". Clin Exp Metastasis. 2011. PMID 21785830.
- "De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures. ". Am J Hum Genet. 2017. PMID 28942967.
- "The distal helix in the regulatory domain of calcineurin is important for domain stability and enzyme function. ". Biochemistry. 2013. PMID 24191726.
- "Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID 22691791.