PRDX2

PRDX2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1QMV
Dynodwyr
Cyfenwau	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
Dynodwyr allanol	OMIM: 600538 HomoloGene: 21182 GeneCards: PRDX2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• oxidoreductase activity; • antioxidant activity; • peroxiredoxin activity; • peroxidase activity; • GO:0001948, GO:0016582 protein binding; • thioredoxin peroxidase activity;
Cydrannau o'r gell	• cytoplasm; • extracellular exosome; • cytosol;
Prosesau biolegol	• regulation of apoptotic process; • negative regulation of apoptotic process; • hydrogen peroxide catabolic process; • cell redox homeostasis; • GO:0001306 response to oxidative stress; • cellular response to oxidative stress; • removal of superoxide radicals; • respiratory burst involved in inflammatory response; • regulation of hydrogen peroxide metabolic process; • positive regulation of blood coagulation; • negative regulation of lipopolysaccharide-mediated signaling pathway; • negative regulation of NF-kappaB transcription factor activity; • response to lipopolysaccharide; • T cell proliferation; • hydrogen peroxide metabolic process; • negative regulation of T cell differentiation; • thymus development; • homeostasis of number of cells; • negative regulation of reactive oxygen species metabolic process; • negative regulation of extrinsic apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • leukocyte activation;
	Sources:Amigo / QuickGO
Orthologau
	7001
	n/a
	ENSG00000167815
	n/a
	P32119
	n/a
	NM_181738; NM_005809; NM_181737
	n/a
	NP_005800
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRDX2 yw PRDX2 a elwir hefyd yn Peroxiredoxin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRDX2.

PRP
TSA
PRX2
PTX1
TPX1
NKEFB
PRXII
TDPX1
NKEF-B
HEL-S-2a

Llyfryddiaeth

"Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. ". Stem Cells. 2016. PMID 26866938.
"An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. ". Exp Mol Med. 2015. PMID 26021759.
"Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation. ". Int J Mol Sci. 2017. PMID 28375164.
"Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients. ". Oncotarget. 2017. PMID 28125800.
"Peroxiredoxin-2 up-regulation in inflammatory bowel disease: Friend or foe?". J Gastroenterol Hepatol. 2017. PMID 27869326.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRDX2 - Cronfa NCBI

[1]

[2]