PRKAA2

PRKAA2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2H6D, 2LTU, 2YZA, 3AQV, 4CFE, 4CFF, 4ZHX, 5EZV
Dynodwyr
Cyfenwau	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
Dynodwyr allanol	OMIM: 600497 HomoloGene: 4551 GeneCards: PRKAA2
EC number	2.7.11.27
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • [acetyl-CoA carboxylase kinase activity]; • AMP-activated protein kinase activity; • histone serine kinase activity; • chromatin binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity]; • protein serine/threonine/tyrosine kinase activity; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nucleoplasm; • nucleotide-activated protein kinase complex; • cnewyllyn cell; • Golgi apparatus; • nuclear speck; • cytoplasmic stress granule; • axon; • dendrite; • soma;
Prosesau biolegol	• carnitine shuttle; • steroid metabolic process; • GO:0007243 intracellular signal transduction; • cellular response to glucose starvation; • sterol biosynthetic process; • lipid biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • glucose homeostasis; • positive regulation of autophagy; • phosphorylation; • proses rythmig; • lipid metabolism; • response to stress; • negative regulation of apoptotic process; • cholesterol metabolic process; • Wnt signaling pathway; • regulation of fatty acid biosynthetic process; • fatty acid metabolic process; • transcription, DNA-templated; • cellular response to prostaglandin E stimulus; • autophagy; • protein phosphorylation; • negative regulation of TOR signaling; • positive regulation of macroautophagy; • fatty acid biosynthetic process; • fatty acid homeostasis; • regulation of circadian rhythm; • cellular response to nutrient levels; • regulation of gene expression; • cholesterol biosynthetic process; • response to muscle activity; • positive regulation of glycolytic process; • macroautophagy; • GO:0072468 signal transduction; • steroid biosynthetic process; • regulation of signal transduction by p53 class mediator; • regulation of macroautophagy; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • negative regulation of gene expression; • cellular response to oxidative stress; • regulation of stress granule assembly; • regulation of microtubule cytoskeleton organization; • cellular response to calcium ion; • cellular response to glucose stimulus; • energy homeostasis; • positive regulation of protein localization; • negative regulation of tubulin deacetylation; • positive regulation of peptidyl-lysine acetylation;
	Sources:Amigo / QuickGO
Orthologau
	5563
	n/a
	ENSG00000162409
	n/a
	P54646
	n/a
	NM_006252
	n/a
	NP_006243
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAA2 yw PRKAA2 a elwir hefyd yn Protein kinase AMP-activated catalytic subunit alpha 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p32.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAA2.

AMPK
AMPK2
PRKAA
AMPKa2

Llyfryddiaeth

"Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy. ". Neoplasia. 2006. PMID 16984726.
"AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. ". J Med Genet. 2006. PMID 16801347.
"Prognostic Significance of AMP-Dependent Kinase Alpha Expression in Cervical Cancer. ". Pathobiology. 2015. PMID 26337566.
"Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain. ". Acta Crystallogr D Biol Crystallogr. 2011. PMID 21543851.
"Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action.". Am J Physiol Endocrinol Metab. 2009. PMID 19470831.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRKAA2 - Cronfa NCBI

[1]

[2]