PRKAB1

PRKAB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4CFE, 4CFF, 5EZV, 4ZHX,%%s4ZHX, 5EZV
Dynodwyr
Cyfenwau	PRKAB1, AMPK, HAMPKb, protein kinase AMP-activated non-catalytic subunit beta 1
Dynodwyr allanol	OMIM: 602740 HomoloGene: 38160 GeneCards: PRKAB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein kinase activity; • AMP-activated protein kinase activity; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • kinase activity;
Cydrannau o'r gell	• cytosol; • nucleotide-activated protein kinase complex; • cnewyllyn cell; • nucleoplasm; • GO:0009327 protein-containing complex; • cytoplasm;
Prosesau biolegol	• protein heterooligomerization; • lipid metabolism; • fatty acid metabolic process; • protein phosphorylation; • GO:1901313 positive regulation of gene expression; • fatty acid biosynthetic process; • GO:0048552 regulation of catalytic activity; • macroautophagy; • nail development; • GO:0072468 signal transduction; • positive regulation of cold-induced thermogenesis; • regulation of macroautophagy; • regulation of signal transduction by p53 class mediator; • phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	5564
	n/a
	ENSG00000111725
	n/a
	Q9Y478
	n/a
	NM_006253
	n/a
	NP_006244; NP_006244.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAB1 yw PRKAB1 a elwir hefyd yn Protein kinase, AMP-activated, beta 1 non-catalytic subunit, isoform CRA_a a Protein kinase AMP-activated non-catalytic subunit beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.23.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAB1.

AMPK
HAMPKb

Llyfryddiaeth

"AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. ". Cell Signal. 2011. PMID 21554950.
"Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics. ". Oncol Rep. 2011. PMID 21271224.
"Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer. ". Mol Cancer. 2014. PMID 24602453.
"Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. ". J Lipid Res. 2012. PMID 22323564.
"AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases.". Biochim Biophys Acta. 2012. PMID 22001850.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRKAB1 - Cronfa NCBI

[1]

[2]