PRKAR2B

PRKAR2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3TNP, 3TNQ, 4WBB, 4X6Q
Dynodwyr
Cyfenwau	PRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta
Dynodwyr allanol	OMIM: 176912 HomoloGene: 37666 GeneCards: PRKAR2B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • protein domain specific binding; • protein kinase A catalytic subunit binding; • cAMP binding; • cAMP-dependent protein kinase regulator activity; • cAMP-dependent protein kinase inhibitor activity; • protein kinase binding; • ubiquitin protein ligase binding; • GO:0001948, GO:0016582 protein binding; • 3',5'-cyclic-GMP phosphodiesterase activity; • kinase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • centrosome; • bilen; • Cellbilen; • dendritic spine; • ciliary base; • dendritic shaft; • soma; • dendrite; • perinuclear region of cytoplasm; • mitochondrial inner membrane; • membrane raft; • cAMP-dependent protein kinase complex; • extracellular exosome; • postsynapse; • glutamatergic synapse;
Prosesau biolegol	• regulation of protein phosphorylation; • activation of protein kinase A activity; • GO:0007243 intracellular signal transduction; • response to antipsychotic drug; • cellular response to glucagon stimulus; • blood coagulation; • learning; • negative regulation of cAMP-dependent protein kinase activity; • fatty acid metabolic process; • G2/M transition of mitotic cell cycle; • response to clozapine; • renal water homeostasis; • regulation of protein kinase activity; • ciliary basal body-plasma membrane docking; • regulation of G2/M transition of mitotic cell cycle; • cGMP-mediated signaling; • modulation of chemical synaptic transmission; • phosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	5577
	n/a
	ENSG00000005249; ENSG00000284096
	n/a
	P31323
	n/a
	NM_002736
	n/a
	NP_002727; NP_002727.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKAR2B yw PRKAR2B a elwir hefyd yn Protein kinase, cAMP-dependent, regulatory, type II, beta, isoform CRA_a a Protein kinase cAMP-dependent type II regulatory subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKAR2B.

PRKAR2
RII-BETA

Llyfryddiaeth

"Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells. ". J Immunol. 2003. PMID 14500661.
"Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. ". J Cell Sci. 2001. PMID 11591815.
"Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain. ". Hum Psychopharmacol. 2014. PMID 24737441.
"Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. ". J Biol Chem. 2008. PMID 18544528.
"Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.". Eur J Endocrinol. 2008. PMID 18505904.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRKAR2B - Cronfa NCBI

[1]

[2]