PRKCE

PRKCE
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2WH0
Dynodwyr
Cyfenwau	PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
Dynodwyr allanol	OMIM: 176975 HomoloGene: 48343 GeneCards: PRKCE
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • protein kinase C activity; • actin monomer binding; • 14-3-3 protein binding; • signal transducer activity; • metal ion binding; • signaling receptor activator activity; • protein serine/threonine kinase activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • calcium-independent protein kinase C activity; • enzyme binding; • ethanol binding; • GO:0010577 enzyme activator activity; • ATP binding;
Cydrannau o'r gell	• cytoplasm; • cyrion cell; • cytosol; • Golgi apparatus; • bilen; • Cellbilen; • Reticwlwm endoplasmig; • mitocondria; • perinuclear region of cytoplasm; • Cytosgerbwd; • cnewyllyn cell;
Prosesau biolegol	• positive regulation of cell-substrate adhesion; • release of sequestered calcium ion into cytosol; • regulation of insulin secretion involved in cellular response to glucose stimulus; • positive regulation of cellular glucuronidation; • GO:0007243 intracellular signal transduction; • positive regulation of actin filament polymerization; • cellular response to ethanol; • Fc-gamma receptor signaling pathway involved in phagocytosis; • phosphorylation; • immune system process; • regulation of release of sequestered calcium ion into cytosol; • negative regulation of sodium ion transmembrane transporter activity; • positive regulation of lipid catabolic process; • positive regulation of wound healing; • positive regulation of epithelial cell migration; • positive regulation of synaptic transmission, GABAergic; • TRAM-dependent toll-like receptor 4 signaling pathway; • locomotory exploration behavior; • platelet activation; • positive regulation of cytokinesis; • Cellraniad; • negative regulation of protein ubiquitination; • protein phosphorylation; • macrophage activation involved in immune response; • response to morphine; • positive regulation of signaling receptor activity; • regulation of lipid metabolic process; • cell adhesion; • cellular response to prostaglandin E stimulus; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • cell cycle; • positive regulation of mucus secretion; • positive regulation of fibroblast migration; • cellular response to hypoxia; • lipopolysaccharide-mediated signaling pathway; • GO:0072468 signal transduction; • positive regulation of insulin secretion; • positive regulation of MAPK cascade; • regulation of peptidyl-tyrosine phosphorylation; • GO:0097285 apoptotic process; • positive regulation of protein localization to plasma membrane; • GO:0048554 positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologau
	5581
	n/a
	ENSG00000171132
	n/a
	Q02156
	n/a
	NM_005400
	n/a
	NP_005391
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCE yw PRKCE a elwir hefyd yn Protein kinase C epsilon type a Protein kinase C epsilon (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCE.

PKCE
nPKC-epsilon

Llyfryddiaeth

"Mitotic catenation is monitored and resolved by a PKCÎµ-regulated pathway. ". Nat Commun. 2014. PMID 25483024.
"Knockdown of PKCÎµ expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3. ". J Mol Neurosci. 2015. PMID 24888992.
"PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes. ". Gene. 2016. PMID 27312950.
"PKCÎµ Is an Essential Mediator of Prostate Cancer Bone Metastasis. ". Mol Cancer Res. 2015. PMID 26023164.
"PKCÎµ-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2.". Cell Signal. 2015. PMID 25778903.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRKCE - Cronfa NCBI

[1]

[2]