PRKCG

PRKCG
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2E73, 2UZP
Dynodwyr
Cyfenwau	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma, PKCI(3), PKCgamma
Dynodwyr allanol	OMIM: 176980 HomoloGene: 20602 GeneCards: PRKCG
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • protein kinase activity; • nucleotide binding; • protein kinase C activity; • zinc ion binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • protein serine/threonine/tyrosine kinase activity; • ATP binding; • calcium-dependent protein kinase C activity;
Cydrannau o'r gell	• cytoplasm; • synaptic membrane; • cytosol; • cell projection; • bilen; • cell-cell junction; • Cellbilen; • synapse; • intracellular anatomical structure; • cell junction; • dendrite; • perinuclear region of cytoplasm; • neuron projection; • cnewyllyn cell; • GO:0097483, GO:0097481 postsynaptic density; • calyx of Held; • presynaptic cytosol; • postsynaptic cytosol;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • GO:0007243 intracellular signal transduction; • phosphorylation; • GO:1903363 negative regulation of protein catabolic process; • proses rythmig; • regulation of response to food; • platelet activation; • chemosensory behavior; • negative regulation of protein ubiquitination; • protein phosphorylation; • response to morphine; • positive regulation of mismatch repair; • response to pain; • regulation of circadian rhythm; • GO:0035404 peptidyl-serine phosphorylation; • learning or memory; • protein autophosphorylation; • negative regulation of proteasomal protein catabolic process; • regulation of phagocytosis; • innervation; • chemical synaptic transmission; • response to psychosocial stress; • presynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	5582
	n/a
	ENSG00000126583
	n/a
	P05129
	n/a
	NM_002739; NM_001316329
	n/a
	NP_001303258; NP_002730
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRKCG yw PRKCG a elwir hefyd yn Protein kinase C gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.42.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRKCG.

PKCC
PKCG
SCA14
PKC-gamma

Llyfryddiaeth

"SCA14 mutation V138E leads to partly unfolded PKCÎ³ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization. ". J Neurochem. 2014. PMID 24134140.
"Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. ". Neurology. 2012. PMID 22675081.
"Genetic variations in the PRKCG gene and osteosarcoma risk in a Chinese population: a case-control study. ". Tumour Biol. 2015. PMID 25663494.
"Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility. ". Tumour Biol. 2014. PMID 25252845.
"Increased protein kinase C gamma activity induces Purkinje cell pathology in a mouse model of spinocerebellar ataxia 14.". Neurobiol Dis. 2014. PMID 24937631.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRKCG - Cronfa NCBI

[1]

[2]