PRPF40A

PRPF40A
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UZC, 1YWI, 1YWJ, 1ZR7, 2CQN, 2DYF, 2KZG, 2L5F, 2L9V, 2LKS
Dynodwyr
Cyfenwau	PRPF40A, FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40, pre-mRNA processing factor 40 homolog A
Dynodwyr allanol	OMIM: 612941 HomoloGene: 6377 GeneCards: PRPF40A
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• proline-rich region binding; • GO:0001948, GO:0016582 protein binding; • RNA binding;
Cydrannau o'r gell	• nuclear matrix; • U1 snRNP; • U2-type prespliceosome; • bilen; • cnewyllyn cell; • nucleoplasm; • cytosol; • nuclear speck;
Prosesau biolegol	• Cellraniad; • cell cycle; • mRNA processing; • regulation of cytokinesis; • cell migration; • cytoskeleton organization; • RNA splicing; • regulation of cell shape; • mRNA splicing, via spliceosome; • mRNA cis splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologau
	55660
	n/a
	ENSG00000196504
	n/a
	O75400
	n/a
NM_017892; NM_001354432; NM_001354431; NM_001365596; NM_001365597;
	NM_001365598; NM_001365599; NM_001365600; NM_001365601; NM_001365602; NM_001365603; NM_001365604; NM_001365605; NM_001395472; NM_001395473; NM_001395475; NM_001395476; NM_001395477; NM_001395478; NM_001395479; NM_001395480; NM_001395481; NM_001395482; NM_001395483; NM_001395488
	n/a
NP_060362; NP_001341361; NP_001341360; NP_001352525; NP_001352526;
	NP_001352527; NP_001352528; NP_001352529; NP_001352530; NP_001352531; NP_001352532; NP_001352533; NP_001352534
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRPF40A yw PRPF40A a elwir hefyd yn Pre-mRNA processing factor 40 homolog A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRPF40A.

HYPA
FBP11
FLAF1
FNBP3
HIP10
Prp40
FBP-11
HIP-10
NY-REN-6

Llyfryddiaeth

"Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40. ". J Mol Biol. 2002. PMID 12460579.
"Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA). ". J Biol Chem. 2011. PMID 21566141.
"The effect of C-terminal helix on the stability of FF domain studied by molecular dynamics simulation. ". Int J Mol Sci. 2012. PMID 22408419.
"A transient and low-populated protein-folding intermediate at atomic resolution. ". Science. 2010. PMID 20829478.
"Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.". J Biol Chem. 2006. PMID 17065151.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRPF40A - Cronfa NCBI

[1]

[2]