PRPF8

PRPF8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3E9L, 3ENB, 3LRU, 4JK7, 4JK8, 4JK9, 4JKA, 4JKB, 4JKC, 4JKD, 4JKE, 4JKF, 4JKG, 4JKH, 4KIT, 3JCR
Dynodwyr
Cyfenwau	PRPF8, pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
Dynodwyr allanol	OMIM: 607300 HomoloGene: 4706 GeneCards: PRPF8
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• K63-linked polyubiquitin modification-dependent protein binding; • GO:0001948, GO:0016582 protein binding; • RNA binding; • second spliceosomal transesterification activity; • U6 snRNA binding; • U1 snRNA binding; • U2 snRNA binding; • U5 snRNA binding; • pre-mRNA intronic binding;
Cydrannau o'r gell	• nuclear speck; • catalytic step 2 spliceosome; • bilen; • U5 snRNP; • nucleoplasm; • small nuclear ribonucleoprotein complex; • spliceosomal complex; • cnewyllyn cell; • U4/U6 x U5 tri-snRNP complex; • U2-type precatalytic spliceosome; • U2-type catalytic step 2 spliceosome;
Prosesau biolegol	• mRNA splicing, via spliceosome; • spliceosomal tri-snRNP complex assembly; • RNA splicing, via transesterification reactions; • cellular response to tumor necrosis factor; • mRNA processing; • RNA splicing; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologau
	10594
	n/a
	ENSG00000274442; ENSG00000174231
	n/a
	Q6P2Q9
	n/a
	NM_006445
	n/a
	NP_006436
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PRPF8 yw PRPF8 a elwir hefyd yn Pre-mRNA processing factor 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PRPF8.

PRP8
RP13
HPRP8
PRPC8
SNRNP220

Llyfryddiaeth

"Variants in the PRPF8 Gene are Associated with Glaucoma. ". Mol Neurobiol. 2017. PMID 28707069.
"Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. ". J Cell Biol. 2017. PMID 28515276.
"Influenza A virus upregulates PRPF8 gene expression to increase virus production. ". Arch Virol. 2017. PMID 28110426.
"Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength. ". Genome Biol. 2015. PMID 26392272.
"Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.". RNA. 2015. PMID 26385511.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PRPF8 - Cronfa NCBI

[1]

[2]