PSMB1

PSMB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4R3O, 4R67, 5A0Q
Dynodwyr
Cyfenwau	PSMB1, HC5, PMSB1, PSC5, proteasome subunit beta 1, proteasome 20S subunit beta 1
Dynodwyr allanol	OMIM: 602017 HomoloGene: 2087 GeneCards: PSMB1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• endopeptidase activity; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • threonine-type endopeptidase activity; • hydrolase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nucleoplasm; • proteasome complex; • extracellular exosome; • cnewyllyn cell; • proteasome core complex; • extracellular region; • secretory granule lumen; • ficolin-1-rich granule lumen; • proteasome core complex, beta-subunit complex;
Prosesau biolegol	• regulation of cellular amino acid metabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of mRNA stability; • positive regulation of canonical Wnt signaling pathway; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • tumor necrosis factor-mediated signaling pathway; • MAPK cascade; • proteolysis; • Fc-epsilon receptor signaling pathway; • NIK/NF-kappaB signaling; • anaphase-promoting complex-dependent catabolic process; • proteolysis involved in cellular protein catabolic process; • T cell receptor signaling pathway; • negative regulation of canonical Wnt signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • GO:0022415 viral process; • Wnt signaling pathway, planar cell polarity pathway; • negative regulation of G2/M transition of mitotic cell cycle; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • neutrophil degranulation; • transmembrane transport; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • post-translational protein modification; • regulation of hematopoietic stem cell differentiation; • proteasomal protein catabolic process; • proteasomal ubiquitin-independent protein catabolic process; • interleukin-1-mediated signaling pathway; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	5689
	n/a
	ENSG00000008018; ENSG00000281184
	n/a
	P20618
	n/a
	NM_002793
	n/a
	NP_002784
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB1 yw PSMB1 a elwir hefyd yn Proteasome subunit beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q27.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB1.

HC5
PSC5
PMSB1

Llyfryddiaeth

"Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab. ". Clin Cancer Res. 2013. PMID 23549871.
"Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. ". Acta Biochim Biophys Sin (Shanghai). 2004. PMID 14732874.
"Role of nuclear localization of PSMB1 in transcriptional activation. ". Biosci Biotechnol Biochem. 2013. PMID 23924720.
"Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome. ". J Rheumatol. 2013. PMID 23504381.
"[Influence of As(2)O(3) on proteasome beta(1)-subunit in NB4 cells].". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009. PMID 19549367.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMB1 - Cronfa NCBI

[1]

[2]