PSMB2

PSMB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4R3O, 4R67, 1IRU, 5A0Q
Dynodwyr
Cyfenwau	PSMB2, HC7-I, proteasome subunit beta 2, proteasome 20S subunit beta 2
Dynodwyr allanol	OMIM: 602175 HomoloGene: 2088 GeneCards: PSMB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• endopeptidase activity; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • threonine-type endopeptidase activity; • hydrolase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • nucleoplasm; • proteasome complex; • extracellular exosome; • cnewyllyn cell; • proteasome core complex; • proteasome core complex, beta-subunit complex;
Prosesau biolegol	• regulation of cellular amino acid metabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • GO:1904578 response to organic cyclic compound; • regulation of mRNA stability; • positive regulation of canonical Wnt signaling pathway; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • tumor necrosis factor-mediated signaling pathway; • proteolysis; • MAPK cascade; • Fc-epsilon receptor signaling pathway; • NIK/NF-kappaB signaling; • response to organonitrogen compound; • anaphase-promoting complex-dependent catabolic process; • proteolysis involved in cellular protein catabolic process; • T cell receptor signaling pathway; • negative regulation of canonical Wnt signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • Wnt signaling pathway, planar cell polarity pathway; • GO:0022415 viral process; • negative regulation of G2/M transition of mitotic cell cycle; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • transmembrane transport; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • post-translational protein modification; • regulation of hematopoietic stem cell differentiation; • proteasomal protein catabolic process; • proteasomal ubiquitin-independent protein catabolic process; • interleukin-1-mediated signaling pathway; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	5690
	n/a
	ENSG00000126067
	n/a
	P49721
	n/a
	NM_002794; NM_001199779; NM_001199780
	n/a
	NP_001186708; NP_001186709; NP_002785
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB2 yw PSMB2 a elwir hefyd yn Proteasome subunit beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p34.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB2.

HC7-I

Llyfryddiaeth

"The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1. ". PLoS One. 2013. PMID 24244684.
"Crystal structure of the human 20S proteasome in complex with carfilzomib. ". Structure. 2015. PMID 25599644.
"The over-expression of the β2 catalytic subunit of the proteasome decreases homologous recombination and impairs DNA double-strand break repair in human cells. ". J Biomed Biotechnol. 2011. PMID 21660142.
"Beta 2 subunit propeptides influence cooperative proteasome assembly. ". J Biol Chem. 2003. PMID 12456675.
"Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.". Biochim Biophys Acta. 1994. PMID 7918633.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMB2 - Cronfa NCBI

[1]

[2]