PSMB5

PSMB5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4R3O, 4R67, 5A0Q
Dynodwyr
Cyfenwau	PSMB5, LMPX, MB1, proteasome subunit beta 5, X, proteasome 20S subunit beta 5
Dynodwyr allanol	OMIM: 600306 HomoloGene: 55690 GeneCards: PSMB5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• endopeptidase activity; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • threonine-type endopeptidase activity; • hydrolase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • centrosome; • nucleoplasm; • proteasome complex; • extracellular exosome; • cnewyllyn cell; • proteasome core complex; • proteasome core complex, beta-subunit complex;
Prosesau biolegol	• regulation of cellular amino acid metabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • regulation of mRNA stability; • positive regulation of canonical Wnt signaling pathway; • protein polyubiquitination; • stimulatory C-type lectin receptor signaling pathway; • tumor necrosis factor-mediated signaling pathway; • GO:0001306 response to oxidative stress; • proteolysis; • MAPK cascade; • Fc-epsilon receptor signaling pathway; • NIK/NF-kappaB signaling; • anaphase-promoting complex-dependent catabolic process; • proteolysis involved in cellular protein catabolic process; • T cell receptor signaling pathway; • negative regulation of canonical Wnt signaling pathway; • proteasome-mediated ubiquitin-dependent protein catabolic process; • GO:0022415 viral process; • Wnt signaling pathway, planar cell polarity pathway; • negative regulation of G2/M transition of mitotic cell cycle; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • transmembrane transport; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • post-translational protein modification; • regulation of hematopoietic stem cell differentiation; • proteasomal protein catabolic process; • proteasomal ubiquitin-independent protein catabolic process; • interleukin-1-mediated signaling pathway; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	5693
	n/a
	ENSG00000100804
	n/a
	P28074
	n/a
	NM_001130725; NM_001144932; NM_002797
	n/a
	NP_001124197; NP_001138404; NP_002788
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PSMB5 yw PSMB5 a elwir hefyd yn Proteasome subunit beta 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PSMB5.

X
MB1
LMPX

Llyfryddiaeth

"Proteasome subunit β5t expression in cervical ectopic thymoma. ". J Clin Pathol. 2012. PMID 22523338.
"Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. ". Leuk Res. 2012. PMID 21978467.
"Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells. ". J Exp Clin Cancer Res. 2017. PMID 28143565.
"Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. ". Biochem Biophys Res Commun. 2014. PMID 24393841.
"[Expression of proteasome β5 subunit in human atherosclerotic plaque].". Zhonghua Yi Xue Za Zhi. 2012. PMID 22781773.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PSMB5 - Cronfa NCBI

[1]

[2]