PTBP1

PTBP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1QM9, 1SJQ, 1SJR, 2AD9, 2ADB, 2ADC, 2EVZ, 3ZZY, 3ZZZ
Dynodwyr
Cyfenwau	PTBP1, HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, polypyrimidine tract binding protein 1
Dynodwyr allanol	OMIM: 600693 HomoloGene: 49188 GeneCards: PTBP1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• pre-mRNA binding; • GO:0001948, GO:0016582 protein binding; • poly-pyrimidine tract binding; • nucleic acid binding; • RNA binding;
Cydrannau o'r gell	• nucleolus; • extracellular exosome; • bilen; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• mRNA splicing, via spliceosome; • mRNA processing; • negative regulation of mRNA splicing, via spliceosome; • regulation of alternative mRNA splicing, via spliceosome; • negative regulation of RNA splicing; • RNA splicing; • negative regulation of muscle cell differentiation; • fibroblast growth factor receptor signaling pathway; • IRES-dependent viral translational initiation; • RNA metabolic process; • positive regulation of protein dephosphorylation; • positive regulation of calcineurin-NFAT signaling cascade;
	Sources:Amigo / QuickGO
Orthologau
	5725
	n/a
	ENSG00000011304
	n/a
	P26599
	n/a
	NM_002819; NM_031990; NM_031991; NM_175847
	n/a
	NP_002810; NP_114367; NP_114368
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTBP1 yw PTBP1 a elwir hefyd yn Polypyrimidine tract-binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTBP1.

PTB
PTB2
PTB3
PTB4
pPTB
HNRPI
PTB-1
PTB-T
HNRNPI
HNRNP-I

Llyfryddiaeth

"Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway. ". Elife. 2016. PMID 26744779.
"Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes. ". BMC Med Genet. 2015. PMID 25927630.
"Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. ". Elife. 2016. PMID 27882870.
"Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. ". Biochem Soc Trans. 2016. PMID 27528752.
"Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.". Hum Mol Genet. 2016. PMID 27378699.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PTBP1 - Cronfa NCBI

[1]

[2]