PTPN6

PTPN6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ
Dynodwyr
Cyfenwau	PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6, protein tyrosine phosphatase non-receptor type 6
Dynodwyr allanol	OMIM: 176883 HomoloGene: 56589 GeneCards: PTPN6
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phosphoprotein phosphatase activity; • SH3 domain binding; • GO:0098519, GO:0098518 phosphatase activity; • phosphotyrosine residue binding; • SH2 domain binding; • GO:0001948, GO:0016582 protein binding; • transmembrane receptor protein tyrosine phosphatase activity; • hydrolase activity; • protein kinase binding; • cell adhesion molecule binding; • protein tyrosine phosphatase activity; • phosphorylation-dependent protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • cell-cell junction; • alpha-beta T cell receptor complex; • nucleolus; • extracellular exosome; • cnewyllyn cell; • extracellular region; • specific granule lumen; • tertiary granule lumen; • nucleoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• B cell receptor signaling pathway; • megakaryocyte development; • G protein-coupled receptor signaling pathway; • cell differentiation; • GO:0007243 intracellular signal transduction; • regulation of release of sequestered calcium ion into cytosol; • abortive mitotic cell cycle; • T cell costimulation; • GO:0016576 protein dephosphorylation; • platelet formation; • negative regulation of T cell receptor signaling pathway; • platelet activation; • negative regulation of humoral immune response mediated by circulating immunoglobulin; • regulation of G1/S transition of mitotic cell cycle; • negative regulation of T cell proliferation; • regulation of type I interferon-mediated signaling pathway; • negative regulation of peptidyl-tyrosine phosphorylation; • negative regulation of MAP kinase activity; • hematopoietic progenitor cell differentiation; • positive regulation of cell population proliferation; • negative regulation of MAPK cascade; • regulation of ERK1 and ERK2 cascade; • negative regulation of B cell receptor signaling pathway; • peptidyl-tyrosine phosphorylation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of cell adhesion mediated by integrin; • cell population proliferation; • platelet aggregation; • regulation of B cell differentiation; • leukocyte migration; • natural killer cell mediated cytotoxicity; • negative regulation of cell population proliferation; • GO:0098501, GO:0098502, GO:0006286 dephosphorylation; • GO:0097285 apoptotic process; • neutrophil degranulation; • peptidyl-tyrosine dephosphorylation; • cytokine-mediated signaling pathway; • negative regulation of interleukin-6 production; • negative regulation of tumor necrosis factor production; • cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologau
	5777
	n/a
	ENSG00000111679
	n/a
	P29350
	n/a
	NM_002831; NM_080548; NM_080549
	n/a
	NP_002822; NP_536858; NP_536859
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPN6 yw PTPN6 a elwir hefyd yn Protein tyrosine phosphatase, non-receptor type 6 a Tyrosine-protein phosphatase non-receptor type 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPN6.

HCP
HCPH
SHP1
SHP-1
HPTP1C
PTP-1C
SHP-1L
SH-PTP1

Llyfryddiaeth

"Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma. ". Oncol Rep. 2017. PMID 27959415.
"The NF-kB regulates the SHP-1 expression in monocytes in congestive heart failure. ". Front Biosci (Landmark Ed). 2017. PMID 27814644.
"Shp1 function in myeloid cells. ". J Leukoc Biol. 2017. PMID 28606940.
"Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia. ". Br J Haematol. 2017. PMID 28480959.
"Shp1 positively regulates EGFR signaling by controlling EGFR protein expression in mammary epithelial cells.". Biochem Biophys Res Commun. 2017. PMID 28416389.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PTPN6 - Cronfa NCBI

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[2]