PTPRR

PTPRR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2A8B
Dynodwyr
Cyfenwau	PTPRR, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R
Dynodwyr allanol	OMIM: 602853 HomoloGene: 2135 GeneCards: PTPRR
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phosphoprotein phosphatase activity; • GO:0098519, GO:0098518 phosphatase activity; • GO:0001948, GO:0016582 protein binding; • protein tyrosine phosphatase activity; • transmembrane receptor protein tyrosine phosphatase activity; • protein kinase binding; • hydrolase activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • cell junction; • perinuclear region of cytoplasm; • extracellular space; • cytoplasm; • cytosol;
Prosesau biolegol	• GO:0016576 protein dephosphorylation; • in utero embryonic development; • ERBB2 signaling pathway; • regulation of homophilic cell adhesion; • negative regulation of ERK1 and ERK2 cascade; • peptidyl-tyrosine dephosphorylation; • negative regulation of epithelial cell migration; • GO:0098501, GO:0098502, GO:0006286 dephosphorylation;
	Sources:Amigo / QuickGO
Orthologau
	5801
	n/a
	ENSG00000153233
	n/a
	Q15256
	n/a
	NM_001207015; NM_001207016; NM_002849; NM_130846
	n/a
	NP_001193944; NP_001193945; NP_002840; NP_570897
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PTPRR yw PTPRR a elwir hefyd yn Protein tyrosine phosphatase, receptor type R (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q15.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PTPRR.

PTPRQ
EC-PTP
PCPTP1
PTP-SL
PTPBR7

Llyfryddiaeth

"The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis. ". Mol Cancer. 2009. PMID 20015382.
"Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues. ". Histol Histopathol. 2014. PMID 24242166.
"Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function. ". Dev Neuropsychol. 2017. PMID 28467119.
"Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells. ". BMC Cancer. 2015. PMID 25592066.
"Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder.". J Affect Disord. 2012. PMID 22100128.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PTPRR - Cronfa NCBI

[1]

[2]