PUM2

PUM2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3Q0Q, 3Q0R, 3Q0S
Dynodwyr
Cyfenwau	PUM2, PUMH2, PUML2, pumilio RNA binding family member 2
Dynodwyr allanol	OMIM: 607205 HomoloGene: 69183 GeneCards: PUM2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • RNA binding; • mRNA 3'-UTR binding; • miRNA binding;
Cydrannau o'r gell	• perinuclear region of cytoplasm; • cytoplasmic stress granule; • nuclear membrane; • cytoplasm; • cytosol;
Prosesau biolegol	• regulation of chromosome segregation; • GO:1905616 regulation of gene silencing by miRNA; • positive regulation of RIG-I signaling pathway; • regulation of translation; • regulation of mRNA stability; • GO:1905618 positive regulation of gene silencing by miRNA; • stress granule assembly; • posttranscriptional regulation of gene expression; • production of miRNAs involved in gene silencing by miRNA;
	Sources:Amigo / QuickGO
Orthologau
	23369
	n/a
	ENSG00000055917
	n/a
	Q8TB72
	n/a
NM_001282752; NM_001282790; NM_001282791; NM_015317; NM_001352917;
	NM_001352918; NM_001352919; NM_001352920; NM_001352923; NM_001352925; NM_001352926; NM_001352927; NM_001352928; NM_001352929; NM_001352930
	n/a
NP_001269681; NP_001269719; NP_001269720; NP_056132; NP_001339846;
	NP_001339847; NP_001339848; NP_001339849; NP_001339852; NP_001339854; NP_001339855; NP_001339856; NP_001339857; NP_001339858; NP_001339859
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PUM2 yw PUM2 a elwir hefyd yn Pumilio RNA binding family member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PUM2.

PUMH2
PUML2

Llyfryddiaeth

"Candidate mRNAs interacting with fertility protein PUMILIO2 in the human germ line. ". Reprod Biol. 2006. PMID 16967088.
"Bespoke RNA recognition by Pumilios. ". Biochem Soc Trans. 2015. PMID 26517885.
"Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions. ". RNA. 2017. PMID 28138061.
"PUMILIO-2 is involved in the positive regulation of cellular proliferation in human adipose-derived stem cells. ". Stem Cells Dev. 2012. PMID 21649561.
"Polymorphisms of the human PUMILIO2 gene and male sterility.". Mol Reprod Dev. 2007. PMID 17154300.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PUM2 - Cronfa NCBI

[1]

[2]