RAC2

RAC2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DS6, 2W2T, 2W2V, 2W2X
Dynodwyr
Cyfenwau	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C, IMD73A
Dynodwyr allanol	OMIM: 602049 HomoloGene: 55699 GeneCards: RAC2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GTP binding; • protein kinase regulator activity; • GO:0006184 GTPase activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • phagocytic vesicle membrane; • nuclear envelope; • bilen; • focal adhesion; • Cellbilen; • Microffilament; • extracellular exosome; • lamellipodium; • intracellular anatomical structure;
Prosesau biolegol	• regulation of respiratory burst; • lymphocyte aggregation; • regulation of T cell proliferation; • positive regulation of protein targeting to mitochondrion; • regulation of hydrogen peroxide metabolic process; • actin filament organization; • regulation of cell-substrate adhesion; • regulation of neutrophil migration; • bone resorption; • platelet activation; • chemotaxis; • cell projection assembly; • positive regulation of cell population proliferation; • regulation of mast cell chemotaxis; • positive regulation of neutrophil chemotaxis; • regulation of mast cell degranulation; • regulation of protein kinase activity; • positive regulation of lamellipodium assembly; • regulation of small GTPase mediated signal transduction; • actin cytoskeleton organization; • GO:0072468 signal transduction; • small GTPase mediated signal transduction; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	5880
	n/a
	ENSG00000128340
	n/a
	P15153
	n/a
	NM_002872
	n/a
	NP_002863
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAC2 yw RAC2 a elwir hefyd yn Rac family small GTPase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAC2.

Gx
EN-7
HSPC022
p21-Rac2

Llyfryddiaeth

"Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. ". Immunity. 2011. PMID 22018470.
"An evolutionary analysis of RAC2 identifies haplotypes associated with human autoimmune diseases. ". Mol Biol Evol. 2011. PMID 21680873.
"Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2. ". PLoS One. 2015. PMID 26016997.
"RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency. ". J Allergy Clin Immunol. 2015. PMID 25512081.
"Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.". Blood. 2012. PMID 22411871.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RAC2 - Cronfa NCBI

[1]

[2]