RDX

RDX
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
Dynodwyr
Cyfenwau	RDX, DFNB24, radixin
Dynodwyr allanol	OMIM: 179410 HomoloGene: 37707 GeneCards: RDX
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • protein domain specific binding; • ATPase binding; • protein kinase A binding; • cytoskeletal protein binding; • GO:0001948, GO:0016582 protein binding; • actin binding; • RNA binding; • cadherin binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • focal adhesion; • filopodium; • ruffle; • myelin sheath; • Cellbilen; • apical part of cell; • stereocilium; • microvillus; • apical plasma membrane; • cortical actin cytoskeleton; • cleavage furrow; • extracellular exosome; • Cytosgerbwd; • cyrion cell; • lamellipodium; • midbody; • T-tubule; • cell tip; • extracellular space; • cell projection;
Prosesau biolegol	• regulation of cell size; • establishment of endothelial barrier; • microvillus assembly; • regulation of organelle assembly; • establishment of protein localization; • positive regulation of cell migration; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of G1/S transition of mitotic cell cycle; • negative regulation of homotypic cell-cell adhesion; • regulation of actin filament bundle assembly; • GO:1901313 positive regulation of gene expression; • GO:0034259 negative regulation of GTPase activity; • negative regulation of adherens junction organization; • apical protein localization; • actin filament capping; • cellular response to thyroid hormone stimulus; • regulation of cell shape; • protein kinase A signaling; • regulation of ruffle assembly; • positive regulation of protein localization to early endosome; • positive regulation of early endosome to late endosome transport; • negative regulation of cell size; • regulation of Rap protein signal transduction; • cellular response to platelet-derived growth factor stimulus; • barbed-end actin filament capping; • protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologau
	5962
	n/a
	ENSG00000137710
	n/a
	P35241
	n/a
NM_002906; NM_001260492; NM_001260493; NM_001260494; NM_001260495;
	NM_001260496
	n/a
NP_001247421; NP_001247422; NP_001247423; NP_001247424; NP_001247425;
	NP_002897
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RDX yw RDX a elwir hefyd yn Radixin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RDX.

DFNB24

Llyfryddiaeth

"Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo. ". Asian Pac J Cancer Prev. 2012. PMID 22631643.
"A novel splice site mutation in the RDX gene causes DFNB24 hearing loss in an Iranian family. ". Am J Med Genet A. 2009. PMID 19215054.
"Radixin knockdown by RNA interference suppresses human glioblastoma cell growth in vitro and in vivo. ". Asian Pac J Cancer Prev. 2014. PMID 25520109.
"MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer. ". Cancer Lett. 2014. PMID 24933454.
"Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population.". Genet Mol Res. 2014. PMID 24854655.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RDX - Cronfa NCBI

[1]

[2]