REV3L

REV3L
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Dynodwyr
Cyfenwau	REV3L, POLZ, REV3, REV3 like, DNA directed polymerase zeta catalytic subunit
Dynodwyr allanol	OMIM: 602776 HomoloGene: 48147 GeneCards: REV3L
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • DNA binding; • 4 iron, 4 sulfur cluster binding; • nucleotidyltransferase activity; • iron-sulfur cluster binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • DNA-directed DNA polymerase activity; • 3'-5' exonuclease activity;
Cydrannau o'r gell	• nucleoplasm; • nucleolus; • cnewyllyn cell; • zeta DNA polymerase complex;
Prosesau biolegol	• DNA-dependent DNA replication; • error-prone translesion synthesis; • cellular response to DNA damage stimulus; • DNA replication; • GO:0100026 DNA repair; • translesion synthesis; • nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologau
	5980
	n/a
	ENSG00000009413
	n/a
	O60673
	n/a
	NM_001286431; NM_001286432; NM_002912; NM_001372078
	n/a
	NP_001273360; NP_001273361; NP_002903; NP_001359007
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn REV3L yw REV3L a elwir hefyd yn REV3 like, DNA directed polymerase zeta catalytic subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q21.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn REV3L.

POLZ
REV3

Llyfryddiaeth

"Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome. ". PLoS One. 2015. PMID 26462070.
"REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells. ". Oncol Rep. 2015. PMID 26165320.
"Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses. ". DNA Repair (Amst). 2016. PMID 27338670.
"Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. ". Sci Rep. 2016. PMID 26790612.
"REV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.". Oncol Rep. 2016. PMID 26752104.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] REV3L - Cronfa NCBI

[1]

[2]