RHEB

RHEB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1XTQ, 1XTR, 1XTS, 3SEA, 3T5G
Dynodwyr
Cyfenwau	RHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding
Dynodwyr allanol	OMIM: 601293 HomoloGene: 123916 GeneCards: RHEB
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • magnesium ion binding; • GO:0006184 GTPase activity; • GTP binding; • GDP binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • Golgi apparatus; • endoplasmic reticulum membrane; • bilen; • Golgi membrane; • lysosomal membrane; • Reticwlwm endoplasmig; • spliceosomal complex; • extracellular exosome; • endomembrane system; • GO:0097483, GO:0097481 postsynaptic density; • Cellbilen;
Prosesau biolegol	• positive regulation of oligodendrocyte differentiation; • regulation of TOR signaling; • regulation of type B pancreatic cell development; • positive regulation of TOR signaling; • GO:0072468 signal transduction; • regulation of macroautophagy; • negative regulation of cold-induced thermogenesis; • small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	6009
	n/a
	ENSG00000106615
	n/a
	Q15382
	n/a
	NM_005614
	n/a
	NP_005605
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHEB yw RHEB a elwir hefyd yn Ras homolog, mTORC1 binding (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHEB.

RHEB2

Llyfryddiaeth

"Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells. ". Cancer Lett. 2010. PMID 20554106.
"Regulation of androgen receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate cancer cell proliferation. ". Prostate. 2010. PMID 20127734.
"Rheb and Rags come together at the lysosome to activate mTORC1. ". Biochem Soc Trans. 2013. PMID 23863162.
"Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc. ". J Am Chem Soc. 2013. PMID 23409921.
"Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.". J Biol Chem. 2010. PMID 20685651.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RHEB - Cronfa NCBI

[1]

[2]