RHOB

RHOB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2FV8
Dynodwyr
Cyfenwau	RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6, ras homolog family member B
Dynodwyr allanol	OMIM: 165370 HomoloGene: 68377 GeneCards: RHOB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GDP binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • protein kinase binding;
Cydrannau o'r gell	• cytosol; • endosome; • late endosome; • bilen; • late endosome membrane; • focal adhesion; • Cellbilen; • early endosome; • cleavage furrow; • endosome membrane; • extracellular exosome; • cnewyllyn cell; • intracellular anatomical structure; • cytoplasm; • cell cortex; • cell division site; • intracellular membrane-bounded organelle;
Prosesau biolegol	• cell differentiation; • regulation of cell migration; • endosome to lysosome transport; • endothelial tube morphogenesis; • negative regulation of cell cycle; • positive regulation of angiogenesis; • positive regulation of endothelial cell migration; • multicellular organism development; • platelet activation; • cell adhesion; • negative regulation of cell migration; • angiogenesis; • Rho protein signal transduction; • cellular response to ionizing radiation; • protein transport; • intracellular protein transport; • regulation of small GTPase mediated signal transduction; • cellular response to hydrogen peroxide; • GO:0097285 apoptotic process; • small GTPase mediated signal transduction; • positive regulation of apoptotic process; • GO:0015915 transport; • mitotic cytokinesis; • G protein-coupled receptor signaling pathway; • actin filament organization; • regulation of cell shape; • cell migration; • establishment or maintenance of actin cytoskeleton polarity; • regulation of actin cytoskeleton organization; • actin filament bundle assembly;
	Sources:Amigo / QuickGO
Orthologau
	388
	n/a
	ENSG00000143878
	n/a
	P62745
	n/a
	NM_004040
	n/a
	NP_004031
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RHOB yw RHOB a elwir hefyd yn Ras homolog family member B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RHOB.

ARH6
ARHB
RHOH6
MST081
MSTP081

Llyfryddiaeth

"RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma. ". PLoS One. 2016. PMID 27384222.
"RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. ". J Cell Biol. 2016. PMID 27138256.
"RhoB determines tumor aggressiveness in a murine EGFRL858R-induced adenocarcinoma model and is a potential prognostic biomarker for Lepidic lung cancer. ". Clin Cancer Res. 2014. PMID 25320360.
"Critical functions of RhoB in support of glioblastoma tumorigenesis. ". Neuro Oncol. 2015. PMID 25216671.
"An isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant species.". PLoS One. 2014. PMID 25207810.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RHOB - Cronfa NCBI

[1]

[2]